Madness and Memory

The Discovery of Prions-A New Biological Principle of Disease

Stanley B. Prusiner

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In this "utterly fascinating" science memoir, the Nobel Prize-winning author chronicles his revolutionary discovery of a major cause of brain diseases (The New York Times).

In 1997, Stanley B. Prusiner received the Nobel Prize in Physiology or Medicine for his research on devastating brain diseases. That he was the award's sole recipient was entirely appropriate. His struggle to identify the agent responsible for scrapie and mad cow disease in animals, and Creutzfeldt-Jakob disease in humans, had been waged largely alone, and in some cases, in the face of strenuous opposition.

In Madness and Memory, Prusiner recounts the journey to his remarkable discovery of prions-infectious proteins that replicate and cause disease, but surprisingly contain no genetic material. Along the way, he sheds light on the world of contemporary science and the meticulousness and perseverance it requires. Through his telling, the agony and triumph of years of research comes to life, along with fascinating portraits of fellow scientists racing to make breakthrough discoveries.

Prusiner's hypothesis, once considered heresy, now stands as accepted science and provides a path toward conquering such pervasive scourges as Alzheimer's, Parkinson's, Lou Gehrig's, and others diseases.

"Madness and Memory is the story of one of the most important discoveries in recent medical history, and it is also a vivid and compelling portrait of a life in science." -Oliver Sacks, MD, neurologist and author of Hallucinations

“Perhaps not since James D. Watson’s 1968 memoir The Double Helix has the down and dirty business of world-class science been given such an airing.” —Abigail Zuger, MD, The New York Times
“It is a remarkable tale . . . [A] testament to the staggering intellect and courage involved in one of the most exciting discoveries since the DNA double helix.” —Giovanna Mallucci, Nature

“A unique story, yet many elements will be familiar to scientists in competitive fields. It is a cautionary tale about how vicious science can be, but . . . it could also encourage others to stick to their beliefs and rely on careful science as they meet obstacles.” —Ellen Daniell, author of Every Other Thursday: Stories and Strategies from Successful Women Scientists

“Represents a unique and important contribution.” —Daniel P. Perl, Uniformed Services University of the Health Sciences

“A wonderful account of the multiple obstacles confronted by Stanley Prusiner as he transformed an unconventional hypothesis into one of the greatest discoveries of modern science.” —Robert J. Alpern, MD, dean, Yale University School of Medicine

“A strikingly meticulous book and a powerful effort from the heart to tell a large truth in a personal tale.” —Herman Wouk, author of The Winds of War and War and Remembrance

“Stanley Prusiner is a brilliant scientist whose boldness and tenacity enabled him, against all odds and despite near-universal skepticism, to discover and prove the importance of a new class of disease-producing agents—prions—a discovery as fundamental as that of bacteria and viruses. Prions, by subverting the brain’s own proteins, may play a crucial role in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases—and perhaps afford a clue to their prevention. Madness and Memory is the story of one of the most important discoveries in recent medical history, and it is also a vivid and compelling portrait of a life in science.” —Oliver Sacks

Stanley B. Prusiner, MD, is director of the Institute for Neurodegenerative Diseases and professor of neurology at the University of California, San Francisco. The recipient of an array of scientific honors, he was awarded the Nobel Prize in Physiology or Medicine in 1997. He lives in San Francisco.


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Kopierschutz Nein i
Family Sharing Nein i
Text-to-Speech Nein i
Erscheinungsdatum 18.06.2019
Verlag Yale University Press (Ignition)
Seitenzahl 345 (Printausgabe)
Dateigröße 7110 KB
Sprache Englisch
EAN 9780300199260

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