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Produktbild: Treatments from Toxins

Treatments from Toxins The Therapeutic Potential of Clostridial Neurotoxins

432,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

02.11.2006

Abbildungen

schwarz-weiss Illustrationen, farbige Illustrationen, Tabellen, schwarz-weiss

Herausgeber

Foster Keith Alan + weitere

Verlag

Taylor and Francis

Seitenzahl

312

Maße (L/B/H)

24/16,1/2,2 cm

Gewicht

572 g

Sprache

Englisch

ISBN

978-0-8493-2709-4

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

02.11.2006

Abbildungen

schwarz-weiss Illustrationen, farbige Illustrationen, Tabellen, schwarz-weiss

Herausgeber

Verlag

Taylor and Francis

Seitenzahl

312

Maße (L/B/H)

24/16,1/2,2 cm

Gewicht

572 g

Sprache

Englisch

ISBN

978-0-8493-2709-4

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  • Produktbild: Treatments from Toxins
  • INTRODUCTION AND HISTORICAL PERSPECTIVE, K.A. Foster, P. Hambleton, and C.C. ShoneIntroductionNeurotoxigenic ClostridiaDiseases of Botulinum and Tetanus NeurotoxinsClinical Use of Botulinum NeurotoxinsTHREE-DIMENSIONAL PROTEIN STRUCTURES OF LIGHT CHAINS OF BOTULINUM NEUROTOXIN SEROTYPES A, B, AND E AND TETANUS NEUROTOXIN, S. Swaminathan and R.C. StevensStructure of Botulinum Neurotoxin 150kDa HolotoxinProteolysis of Snare Proteins by Botulinum Neurotoxin Light ChainsStructure of Botulinum Neurotoxin Serotype A Light ChainStrucuture of Botulinum Neurotoxin Serotype B Light ChainA Possible Proteolytic Mechanism of Botulinum NeurotoxinsStrudture of Botulinum Neurotoxin Light Chain EStructure of Tetanus Neurotoxin Light ChainConclusionReferencesMECHANISMS OF ACTIONS OF NEUROTOXINS, H. Bigalke and T. BinzIntroductionToxin Uptake, Toxicity, and Clinical Disease ManifestationBinding to Nerve Cell ReceptorsInternalization into the Neuronal CytosolReferencesVACCINES TO PROTECT AGAINST NEUROTOXINS, L.A. Smith and I. HendersonIntroductionToxoid VaccinesRecombinant VaccinesThe Vaccine Candidate RBV A/BConclusionReferencesINHIBITORS OF CLOSTRIDIAL NEUROTOXIN PROTEINASE ACTIVITIES, J.J. Schmidt and K.A. FosterInhibitors if Clostridial Neurotoxin Proteinase ActivitiesNeutralizing AntibodiesConclusionReferencesINTRODUCTION TO CLINICAL USE OF BOTULINUM NEUROTOXINS, M.P. BarnesIntroductionTheory of Clinical UsePractical Aspects of Injection TechniqueLonger Term Side Effects and ProblemsLogistics and CostDystoniaSpasticityConclusionsReferencesEXPANDING CLINICAL USES OF BOTULINUM NEUROTOXINS, A.P. MooreIntroductionNew IndicationsThe Future: Other Possible Indications and SpeculationConclusionsDEVELOPMENT OF THERAPEUTICS BASED UPON CLOSTRIDIAL ENDOPEPTIDASE ACTIVITY, K.A. Foster and J.A. ChaddockIntroductionClostridial Neurotoxin Structure and Function: The 'Endopeptidase' DomainRecombinant Expression of the LHN/ARationale for Use of the LHN EndopeptidasePainThe Potential Use of Neurotoxins Endopeptidase Fragments for Pain ReleifAlternative Therapeutic PossibilitiesConclusionsReferencesUSE OF NEUROTOXINS AS DRUG DELIVERY SYSTEMS, P. ForanOverviewGeneration of Non-Toxic Derivatives Retaining Neuronal Targeting and Delivery Capabilities Using Classical Biochemical Mehtods or Recombinant MeansThe Diverse Neuronal Targeting and Cell Trafficking Pathways Exerted by Clostridial NeurotoxinsIn Vitro or In Vivo Neuronal Targeting Achievements Made Using Innocuous Derivatives: But Not Demonstrating Cytosolic TransferAchievements of Cell or Neuronal Targeting, as well as, Cytoplasmic Delivery of Foreign Cargos Using Innocuous DerivativesImportant Structural Features Proven Essential For Efficient In Vivo Neuronal Targeting and Cytoplasmic Delivery of CargoStrategies for the Efficient Linkage of Therapeutic Adducts to Transporters: Approaches that Ensure Optimal Linkage Efficiency and OrientationPotential Diseases that May be Targeted Using Innocuous BoNT- or TeNT-based Neuron Delivery VehiclesHow Much Cargo can BoNT-Based Transporters Deliver?The Varied Intracellular Trafficking and Site-Specific Delivery Addresses Anticipated for Cargos Linked to BoNT-or TeNT-based VehiclesConclusionReferencesCONCLUSIONS AND FUTURE PERSPECTIVES: BOTULINUM NEUROTOXINS AS PARADIGMS FOR DEVELOPMENT OF MICROBIAL EFFECTOR-DERIVED DRUGS, J.M. SuttonIntroductionTo Kill or Not to Kill: Strategies for Toxin TherapeuticsGeneral Themes for the Future Development of Bacterial Effector-Based TherapeuticsReferencesIndex