Table of Contents
I. Genetics and Regulation
Two Component Systems, Scott Stibitz
Regulation of Bacterial Toxin Synthesis by Iron, Shelley M. Payne
AraC Family Regulators and Transcriptional Control of Bacterial Virulence Determinants, Dara W. Frank and Meredith L. Hunt
Quorum Sensing, Everett C. Pesci and Barbara H. Iglewski
II. Toxin Biogenesis: Crossing Bacterial Membrane Barriers
Box 1: Type V Export Systems, Proteins That Export Themselves, Drusilla L. Burns
The Type I Export Mechanism, Vassilis Koronakis, Jeyanthy Eswaran, and Colin Hughes
Toxins and Type II Secretion Systems, Maria E. Scott and Maria Sandkvist
Type III Secretion Systems, Gregory V. Plano, Kurt Schesser, and Matthew L. Niles
Box 2: Pathogenicity Islands, Jorg Hacker
Type IV Secretion Systems, Drusilla L. Burns
III. Toxin Delivery Into Eukaryotic Cells
Receptors for Bacterial Toxins, Catharine B. Saelinger
Box 3: Domain Structures of Bacterial Toxins, Stephen H. Leppla
Box 4: Recombinant Immunotoxins, David J. FitzGerald, Robert J. Kreitman, and Ira Pastan
Direct Penetration of Bacterial Toxins Across the Plasma Membrane, Franca R. Zaretzky, Mary C. Gray, and Erik L. Hewlett
Transport of Toxins Across Intracellular Membranes, Kirsten Sandvig
Transcytosis of Bacterial Toxins Across Mucosal Barriers, Bonny L. Dickinson and Wayne I. Lencer
Box 5: Lipid Rafts, Bonny L. Dickinson and Wayne I. Lencer
IV. Toxin Action
Membrane-Damaging Toxins: Pore Formation, F. Gisou van der Goot
Box 6: The Vacuolating Toxin VacA of Helicobacter pylori, F. Gisou van der Goot
Membrane-Damaging Toxins: Family of RTX Toxins, Camilla Oxhamre and Agneta Richter-Dahlfors
Bacterial Toxins that Covalently Modify Eukaryotic Proteins by ADP-Ribosylation, Joseph T. Barbieri and Drusilla L. Burns
Box 7: Discovery that the Active Sites of Pseudomonas aeruginosa Exotoxin A and the Heat-Labile Enterotoxin of Escherichia coli Are Superimposable, Wim Hol
Glucosylating and Deamidating Bacterial Protein Toxins, Klaus Aktories
Plant and Bacterial Toxins as RNA N-Glycosidases, Angela Melton-Celsa and Alison D. O'Brien
Cytolethal Distending Toxin, Lawrence A. Dreyfus
Proteases, Ornella Rossetto, Fiorella Tonella, and Cesare Montecucco
Box 8: Landmarks in Tetanus and Botulinum Research, Ornella Rossetto, Fiorella Tonella, and Cesare Montecucco
Bacterial Toxins that Modulate Rho GTPase Activity, James B. Bliska and Gloria I. Viboud
Staphylococcal and Streptococcal Superantigens, Patrick M. Schlievert
V. Bacterial Toxins: Friends and Foes
Toxins as Vaccines and Adjuvants, Mariagrazia Pizza, Vega Masignani, and Rino Rappuoli
Nefarious Uses of Bacterial Toxins, Drusilla L. Burns and Joseph T. Barbieri
