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Produktbild: Green Chemistry in the Pharmaceutical Industry
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Green Chemistry in the Pharmaceutical Industry

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

10.03.2010

Abbildungen

schwarz-weiss Illustrationen, farbige Illustrationen

Herausgeber

Peter Dunn + weitere

Verlag

Wiley-VCH

Seitenzahl

388

Maße (L/B/H)

24,6/17,9/2,5 cm

Gewicht

858 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32418-7

Beschreibung

Rezension

"At last! A book which looks at Green Chemistry from an industrial viewpoint! This is the best book I have read on Green Chemistry and should be on the bookshelf of every process chemist and engineer. Outstanding!" ( Organic Process Research & Development , March 2010)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

10.03.2010

Abbildungen

schwarz-weiss Illustrationen, farbige Illustrationen

Herausgeber

Verlag

Wiley-VCH

Seitenzahl

388

Maße (L/B/H)

24,6/17,9/2,5 cm

Gewicht

858 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32418-7

Herstelleradresse

Wiley-VCH GmbH
product_safety@wiley.com
Wiley-VCH GmbH, Boschstrasse 12, DE-69469 Weinheim

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  • Produktbild: Green Chemistry in the Pharmaceutical Industry
  • INTRODUCTION TO GREEN CHEMISTRY, ORGANIC SYNTHESIS AND PHARMACEUTICALS
    The Development of Organic Synthesis
    The Environmental Factor
    The Role of Catalysis
    Green Chemistry: Benign by Design
    Ibuprofen Manufacture
    The Question of Solvents: Alternative Reaction Media
    Biocatalysis: Green Chemistry Meets White Biotechnology
    Conclusions and Prospects
    GREEN CHEMISTRY METRICS
    Introduction
    Measuring Resource Usage
    Life Cycle Assessment (LCA)
    Measuring Chemistry and Process Efficiency
    Measuring Process Parameters and Emissions
    Real Time Analysis
    Operational Efficiency
    Measuring Energy
    Measuring the Toxicity of All the Substrates
    Measuring Degradation Potential
    Measuring the Inherent Safety of Lack of Inherent Safety
    Conclusions
    SOLVENT USE AND WASTE ISSUES
    Introduction to Solvent Use and Waste Issues
    Solvent and Process Greenness Scoring and Selection Tools
    Waste Minimization and Solvent Recovery
    ENVIRONMENTAL AND REGULATORY ASPECTS
    Historical Perspective
    Pharmaceuticals in the Environment
    Environmental Regulations
    A Look to the Future
    SYNTHESIS OF SITAGLIPTIN, THE ACTIVE INGREDIENT IN JANUVIA AND JANUMET
    Introduction
    First-Generation Route
    Sitagliptin through Diastereoselective Hydrogenation of an Enamine. The PGA Enamine-Ester Route
    The Triazole Fragment
    Direct Preparation of Beta-Keto Amides
    Second-Generation Chiral Auxiliary Route. The PGA Enamine-Amide Route
    Prufication and Isolation of Sitagliptin (Pharmaceutical Form)
    The Final Manufacturing Route
    THE DEVELOPMENT OF SHORT, EFFICIENT, ECONOMIC, AND SUSTAINABLE CHEMOENZYMATIC PROCESSES FOR STATIN SIDE CHAINS
    Introduction: Biocatalysis
    The Relevance of Statins
    Biocatalytic Routes to Statin Side Chains
    2-Deoxy-D-Ribose 5-Phosphate Aldolase (DERA)-Based Routes to Statin Intermediates
    Conclusions
    THE TAXOL STORY-DEVELOPMENT OF A GREEN SYNTHESIS VIA PLANT CELL FERMENTATION
    Introduction
    Discovery and Early Development
    From Extraction of Taxol from Pacific Yew Tree Bark to Semi-Synthetic Taxol
    Taxol from Plant Cell Fermentation
    Comparison of Semi-Synthetic versus PCF Taxol Processes: The Environmental Impact
    Comparison of Semi-Synthetic versus PCF Taxol: Green Chemistry Principles
    Final Words
    THE DEVELOPMENT OF A GREEN, ENERGY EFFICIENT, CHEMOENZYMATIC MANUFACTURING PROCESS OF PREGABALIN
    Introduction
    Process Routes to Pregabalin
    Biocatalytic Route to Pregabalin
    Green Chemistry Considerations
    Conclusions
    GREEN PROCESSES FOR PEPTIDE MIMETIC DIABETIC DRUGS
    Introduction
    Green Chemistry Considerations in Peptide-like API manufacture
    Purification Process to Manufacture Amorphous API
    Preparation of Unnatural Amino Acids
    Summary
    THE DEVELOPMENT OF AN ENVIRONMENTALLY SUSTAINABLE PROCESS FOR RADAFAXINE
    Introduction
    Chemistry Process and the Dynamic Kinetic Resolution (DKR)
    Multicolumn Chromatography - Development of Route 4
    Environmental Assessment
    Summary
    CONTINUOUS PROCESSING IN THE PHARMACEUTICAL INDUSTRY
    Introduction
    Continuous Production of a Key Intermediate for Atorvastatin
    Continuous Process to Prepare Celecoxib
    Continuous Oxidation of Alcohols to Aldehydes
    Continuous Production of Bromonitromethane
    Continuous Production and Use of Diazomehtane
    A Snapshot of Some Further Continuous Processes Used in the Preparation of Pharmaceutical Agents
    Conclusions
    PREPARATIVE AND INDUSTRIAL SCALE CHROMATOGRAPHY: GREEN AND INTEGRATED PROCESSES
    Introduction
    Basic Principles of Chromatography
    Process Optimization to Reduce Eluent Consumption
    Use of a Green Solvent: Supercritical Carbon Dioxide
    Solvent Recycling Technologies
    Application Examples
    Conclusion: An Environmentally Friendly Solution for Each Separation
    DYNAMIC RESOLUTION OF CHIRAL AMINE PHARMACEUTICALS: TURNING WASTE ISOMERS INTO USEFUL PRODUCT
    Background
    Integration of Chiral Amine Resolution and Racemization
    Case Studies
    Conclusions
    GREEN TECHNOLOGIES IN THE GENERIC PHARMACEUTICAL INDUSTRY
    Introduction
    ´Waste´: Definition and Remedy
    Amidation
    Synthesis of Galanthamine
    Synthesis of Solefinacin
    Synthesis of Levetiracetam
    Synthesis of a Finasteride Intermediate
    Bromination
    Sulfoxidation in the Synthesis of Rabeprazole
    Conclusions
    ENVIRONMENTAL CONSIDERATIONS IN BIOLOGICS MANUFACTURE
    Introduction
    Therapeutic Biologics
    Environmental Impact Considerations
    Overall Comparison
    Environmental Indices for Therapeutic Protein Manufacture
    Technologies with Potential Environmental Impact
    Single-Use Biologics Manufacture
    Summary
    FUTURE TRENDS FOR GREEN CHEMISTRY IN THE PHARMACEUTICAL INDUSTRY
    Introduction
    Waste Minimization in Drug Discovery
    Greener Synthetic Methods in Primary Manufacturing
    Alternative Solvents in the Pharmaceutical Industry
    Green Chemistry in Secondary Pharmaceutical Operations
    Global Cooperation in Green Chemistry
    Conclusions