Produktbild: Obsessive Compulsive Disorder

Obsessive Compulsive Disorder Current Science and Clinical Practice

138,99 €

inkl. gesetzl. MwSt., Versandkostenfrei


Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

13.08.2012

Herausgeber

Joseph Zohar

Verlag

John Wiley & Sons

Seitenzahl

360

Maße (L/B/H)

24,6/17,5/2,3 cm

Gewicht

703 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-71125-5

Beschreibung

Rezension

"This is an extremely useful book for anyone who wishes to extend their knowledge and develop services for OCD.As well as presenting the science behind OCD, the outcomes of various therapeutic interventons are also examined.This is a useful additionl to the literature and would recommend it to all adult and child psychiatrists who may wonder how to treat these patients." ( British Journal of Psychiatry, 2013 )

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

13.08.2012

Herausgeber

Joseph Zohar

Verlag

John Wiley & Sons

Seitenzahl

360

Maße (L/B/H)

24,6/17,5/2,3 cm

Gewicht

703 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-71125-5

Herstelleradresse

Produktsicherheitsverantwortliche/r
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

Kundinnen und Kunden meinen

0 Bewertungen

Informationen zu Bewertungen

Zur Abgabe einer Bewertung ist eine Anmeldung im Konto notwendig. Die Authentizität der Bewertungen wird von uns nicht überprüft. Wir behalten uns vor, Bewertungstexte, die unseren Richtlinien widersprechen, entsprechend zu kürzen oder zu löschen.

Die Bewertungen sind nach Format, Anzahl Sterne und Datum sortiert.

Verfassen Sie die erste Bewertung zu diesem Artikel

Helfen Sie anderen Kund*innen durch Ihre Meinung

Kundinnen und Kunden meinen

0 Bewertungen filtern

Die Leseprobe wird geladen.
  • Produktbild: Obsessive Compulsive Disorder
  • List of Contributors xii

    Introduction xvii

    SECTION 1 ASSESSMENT AND TREATMENT

    1 Assessment 3
    Jose M. Menchon

    Introduction 3

    Detecting OCD 5

    Screening in clinical interview 7

    Structured interviews 8

    Clinical assessment of obsessive-compulsive symptoms 9

    Yale-brown obsessive-compulsive scale 10

    Dimensional yale-brown obsessive-compulsive scale (DY-BOCS) 11

    Leyton obsessional inventory (LOI) 12

    Maudsley obsessional-compulsive inventory (MOCI) 13

    Padua inventory (PI) 13

    Obsessive compulsive inventory (OCI) 14

    Insight 14

    Rating insight 15

    Assessment of the risk of suicide 17

    Differential diagnosis, comorbidities and related disorders 18

    Organic brain disorders 19

    Schizophrenia 20

    Depression 20

    Hypochondriasis 20

    Phobias 21

    Tourette disorder and tic disorders 21

    Obsessive-compulsive personality disorder (OCPD) 21

    Body dysmorphic disorder (BDD) 21

    Hoarding 22

    Other disorders 22

    Conclusions 22

    References 23

    2 Pharmacotherapy of obsessive-compulsive disorder 31
    Eric H. Decloedt and Dan J. Stein

    Introduction 31

    Placebo-controlled studies of clomipramine 32

    Placebo-controlled studies of fluvoxamine 32

    Placebo-controlled studies of fluoxetine 33

    Placebo-controlled studies of paroxetine 34

    Placebo-controlled studies of sertraline 34

    Placebo-controlled studies of citalopram/escitalopram 34

    Placebo-controlled studies of venlafaxine 35

    Improving early response in OCD 35

    Special populations: children 36

    Clomipramine 36

    Fluvoxamine 36

    Fluoxetine 36

    Paroxetine 37

    Sertraline 37

    Citalopram 38

    Meta-analyses 38

    Tolerability of clomipramine and serotonin reuptake inhibitors 40

    Optimal dose of treatment 41

    Duration of treatment 42

    Refractory OCD 43

    Increased dose of SSRI 43

    Augmentation of SSRI treatment with antipsychotics 44

    Other drugs 45

    Alternative modes of administration of SSRIs 46

    Combining SRIs 46

    Switching SSRIs 46

    Adding psychotherapy 47

    Future therapeutic options 47

    Conclusion 48

    References 48

    3 Cognitive behavioural therapy in obsessive-compulsive disorder: state of the art 58
    Martin E. Franklin, Addie Goss and John S. March

    Theoretical models 58

    Treatment 60

    Exposure plus response prevention (ERP) 60

    Cognitive therapies 63

    ERP plus medication 63

    OCD protocols 64

    Assessment 64

    Adult ERP protocol 65

    Paediatric ERP protocol 67

    Dissemination 67

    Future research 69

    Summary 69

    References 70

    4 Electroconvulsive therapy, transcranial magnetic stimulation and deep brain stimulation in OCD 75
    Rianne M. Blom, Martijn Figee, Nienke Vulink and Damiaan Denys

    Introduction 75

    Electroconvulsive therapy 75

    Transcranial magnetic stimulation 76

    Mechanism of action 77

    Efficacy of rTMS in OCD 77

    Side effects and safety 84

    Conclusion and future directions 85

    Lesioning 85

    Deep brain stimulation 86

    Efficacy of DBS in OCD 86

    Mechanism of action of DBS in OCD 92

    Side effects of DBS in OCD 92

    Follow-up treatment 94

    Conclusions: DBS 94

    Conclusion 94

    Acknowledgements 95

    References 95

    5 Approaches to treatment resistance 99
    Stefano Pallanti, Giacomo Grassi and Andrea Cantisani

    Terminological problems and operational definitions 100

    Pharmacological strategies in resistant OCD 103

    Switching 103

    Infusion therapy 104

    Cognitive behavioural therapy 105

    Serotoninergic agents 106

    Dopaminergic agents 108

    Glutamatergic agents 113

    Opioids 115

    Physical therapies 115

    Electroconvulsive therapy (ECT) 115

    Repetitive transcranial magnetic stimulation (rTMS) 116

    Deep brain stimulation (DBS) 116

    Family intervention 117

    Conclusions and future perspectives 117

    References 118

    SECTION 2 CLINICAL SPOTLIGHTS

    6 Subtypes and spectrum issues 135
    Eric Hollander, Steven Poskar and Adriel Gerard

    The obsessive-compulsive spectrum 135

    Introduction 135

    Cluster approach 135

    Compulsivity and impulsivity 137

    Repetitive behaviour domain 138

    Determining placement of proposed OCSDs using cross-cutting domains 139

    Obsessive-compulsive spectrum nosology 144

    OCD subtypes: understanding the heterogeneity of OCD 148

    Dimensional approach 148

    Associated symptom domains 150

    Compulsive hoarding: OCPD, OCD subtype, dimension, OCSD or something else? 151

    Conclusion 154

    References 154

    7 Paediatric OCD: developmental aspects and treatment considerations 160
    Daniel A. Geller, Alyssa L. Faro, Ashley R. Brown and Hannah C. Levy

    Introduction 160

    Epidemiology 160

    Aetiological considerations 161

    Genetic factors 161

    Non-genetic factors 164

    Aetiology: summary 167

    Clinical features 167

    Gender and age at onset 168

    Elaboration of phenotypic dimensions 168

    Comorbid conditions 169

    Neuropsychological endophenotypes 170

    Clinical features: summary 170

    Clinical assessment 171

    Differential diagnosis 172

    Normal development 172

    Other psychiatric disorders 172

    Treatment 173

    Pharmacotherapy 174

    Moderating effect of comorbid conditions 175

    Multimodal treatment 176

    Medication augmentation strategies in treatment resistance 177

    Safety and tolerability 178

    Treatment: summary 178

    Course and prognosis 179

    Conclusions and future research 179

    Acknowledgements 180

    References 180

    SECTION 3 RESEARCH SPOTLIGHTS

    8 Methodological issues for clinical treatment trials in obsessive-compulsive disorder 193
    Samar Reghunandanan and Naomi A. Fineberg

    Introduction 193

    Randomized controlled trials 194

    The rationale of placebo 196

    Recruitment criteria 199

    Diagnosis 199

    OCD dimensions and subtypes 200

    The problem of comorbidity 201

    Rating scales for OCD trials 203

    Evaluating anxiety and depression in OCD 204

    Measuring response and remission 205

    Relapse prevention 207

    Treatment-resistant OCD 208

    Psychological treatment trials 209

    Integrated pharmacological and psychological treatments in OCD 210

    Health-related quality of life 211

    Summary 211

    References 212

    9 Serotonin and beyond: a neurotransmitter perspective of OCD 220
    Anat Abudy, Alzbeta Juven-Wetzler, Rachel Sonnino and Joseph Zohar

    Serotonin 221

    Serotonin and metabolite concentrations in OCD - 30 years later 222

    Pharmacological challenge tests 224

    Pharmacotherapy 225

    Animal models and the role of serotonin 226

    Dopamine 227

    Dopamine and metabolite concentrations in humans 227

    Pharmacological challenge tests 228

    Pharmacotherapy 229

    Animal models and the role of dopamine 231

    Glutamate 232

    The glutamatergic influence 232

    Glutamate and metabolite concentrations in humans 232

    Animal models and the role of glutamate 233

    Serotonin: is it the one to blame? 233

    The puzzle of antipsychotics and OCD: Is dopamine the answer? 234

    So, is it a question of location? (Or . . . location, location, location?) 234

    References 235

    10 Brain imaging 244
    David R. Rosenberg, Phillip C. Easter and Georgia Michalopoulou

    Neuroimaging modalities 244

    Structural assessment 244

    Functional neurochemical assessment 245

    Structural assessment of OCD 246

    Total brain volume/ventricles 246

    Basal ganglia 246

    Prefrontal cortex 248

    Medial temporal-limbic cortex 252

    Pituitary 253

    Supramarginal gyrus 253

    White matter 254

    Functional neuroimaging studies of OCD 255

    Neurochemistry 258

    Serotonin 258

    N-acetyl-aspartate 258

    Choline 259

    Creatine/phosphocreatine 262

    Glutamate 262

    Conclusion 266

    Acknowledgements 267

    References 268

    11 The genetics of obsessive-compulsive disorder: current status 277
    David L. Pauls

    Introduction 277

    Twin studies 277

    Family studies 279

    Family history studies 280

    Family interview studies 280

    Segregation analyses 284

    Candidate gene studies 285

    Genetic linkage studies 290

    Future work 291

    Acknowledgements 292

    References 292

    12 Neurocognitive angle: the search for endophenotypes 300
    Samuel R. Chamberlain and Lara Menzies

    Introduction 300

    Heritability of OCD 301

    The concept of an endophenotype 302

    Applying the endophenotype construct to OCD 305

    Domains of interest in hierarchical modelling of OCD 307

    Cognition 307

    Neuroimaging 308

    Searching for endophenotypes of OCD 311

    Cognition 311

    Neuroimaging 313

    Other potential endophenotypes 316

    Summary 317

    Acknowledgements and disclosures 319

    References 320

    13 Conclusion and future directions 327
    Joseph Zohar

    References 329

    Index 331