Produktbild: Predictive Approaches in Drug Discovery and Development
Band 11

Predictive Approaches in Drug Discovery and Development Biomarkers and in Vitro / In Vivo Correlations

186,99 €

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

21.03.2012

Herausgeber

J. Andrew Williams + weitere

Verlag

John Wiley & Sons Inc

Seitenzahl

416

Maße (L/B/H)

24/16,1/2,6 cm

Gewicht

777 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-17083-0

Beschreibung

Rezension

"The ability to correlate in vitro and in vivo biomarker information in the process of drug discovery and development lies at the heart of translational research. The goal is to rapidly translate basic discoveries into clinical applications. This book provides state of the art information on this exciting new research approach." ( Doody's , 8 February 2013) "The text is packed with interesting, comprehensive, and pertinent information, clearly presented with salient points reinforced by inclusion in text boxes . . . This is an admirable textbook for those dealing with drug discovery and development. I enjoyed reading through it and I would recommend it to anyone who has an interest, or is developing an interest, in the field of biomarkers and their, as yet, unfulfilled potential." ( ISSX International Society for the Study of Xenobiotics , 1 December 2012)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

21.03.2012

Herausgeber

Verlag

John Wiley & Sons Inc

Seitenzahl

416

Maße (L/B/H)

24/16,1/2,6 cm

Gewicht

777 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-17083-0

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Predictive Approaches in Drug Discovery and Development
  • PREFACE xi
     
    ACKNOWLEDGMENTS xiii
     
    CONTRIBUTORS xv
     
    PART I BIOMARKERS IN DRUG DISCOVERY 1
     
    1 The Importance of Biomarkers in Translational Medicine 3
    Joseph C. Fleishaker
     
    2 Validation of Biochemical Biomarker Assays used in Drug Discovery and Development: A Review of Challenges and Solutions 23
    Gabriella Szekely-Klepser and Scott Fountain
     
    3 Proteomic Methods to Develop Protein Biomarkers 49
    Ruth A. VanBogelen and Diane Alessi
     
    4 Overview of Metabolomics Basics 79
    Qiuwei Xu and William H. Schaefer
     
    PART II CLINICAL APPLICATION OF BIOMARKERS 139
     
    5 Vascular Biomarkers and Imaging Studies 141
    Karin Potthoff, Ulrike Fiedler, and Joachim Drevs
     
    6 Cardiovascular Biomarkers as Examples of Success and Failure in Predicting Safety in Humans 163
    Simon Authier, Michael K. Pugsley, Eric Troncy, and Michael J. Curtis
     
    7 The Use of Molecular Imaging for Receptor Occupancy Decision Making in Drug Development 189
    Ralph Paul Maguire
     
    8 Biosensors for Clinical Biomarkers 203
    Sara Tombelli and Marco Mascini
     
    PART III REGULATORY PERSPECTIVES 229
     
    9 Regulatory Perspectives on Biomarker Development 231
    Rajanikanth Madabushi, Lawrence Lesko, and Janet Woodcock
     
    10 Perspectives from the European Regulatory Authorities 255
    Ian Hudson
     
    11 Use of Biomarker in Drug Development--Japanese
    Perspectives 269 Yoshiaki Uyama, Akihiro Ishiguro, Harumasa Nakamura,and Satoshi Toyoshima
     
    PART IV PREDICTING IN VIVO 289
     
    12 In Vitro-In Vivo Correlations of Hepatic Drug Clearance 291
    R. Scott Obach
     
    13 The Potential of In Silico and In Vitro Approaches to Predict In Vivo Drug-Drug Interactions and ADMET/TOX Properties 307
    Kenneth Bachmann and Sean Ekins
     
    14 In Vitro-In Vivo Correlations in Drug Discovery and Development: Concepts and Applications in Toxicology 331
    Rex Denton, Kimberly Brannen, and Bruce D. Car
     
    15 Assessing the Potential for Induction of Cytochrome P450 Enzymes and Predicting the In Vivo Response 353
    Jiunn H. Lin
     
    INDEX 383