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Produktbild: Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

02.07.2012

Herausgeber

Peter W. Sutton + weitere

Verlag

John Wiley & Sons

Seitenzahl

388

Maße (L/B/H)

25,1/17,5/2,3 cm

Gewicht

726 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-99139-7

Beschreibung

Rezension

"In conclusion, the second volume of Practical Methods forBiocatalysis and Biotransformations is highly recommended, both tothe nonspecialist in the area and to experts, too." (Organic Process Research & Development Journal, 1 April2013)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

02.07.2012

Herausgeber

Verlag

John Wiley & Sons

Seitenzahl

388

Maße (L/B/H)

25,1/17,5/2,3 cm

Gewicht

726 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-99139-7

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Practical Methods for Biocatalysis and Biotransformations 2
  • List of Contributors ix

    Abbreviations xxiii

    1 Biocatalysis in the Fine Chemical and PharmaceuticalIndustries 1

    1.1 Introduction 1

    1.2 Biotrans Outsourcing - AstraZeneca 4

    1.3 Biotrans Trends - Lonza 5

    1.4 Biocatalysis in the Pharma Environment 9

    1.5 Industrial Use of Hydrolases 24

    1.6 Industrial Biooxidation and Reduction 32

    1.7 Industrial Application of Transaminases - Cambrex36

    1.8 Biocatalyst Discovery and Improvement 38

    1.9 From Pathway Engineering to Synthetic Biology 42

    1.10 Prioritization of Future Biocatalysis and Synthetic BiologyNeeds 47

    1.11 Concluding Remarks 52

    2 Reductive Amination 61

    2.1 o-Transaminases - Useful Biocatalysts for Chiral AmineSynthesis 61

    2.2 Preparative Scale Production of a Bulky-Bulky ChiralAmine Using an Engineered Transaminase 64

    2.3 Synthesis of Optically Pure Amines Employing o-Transaminases69

    2.4 A Fast, Sensitive Assay and Scale-Up of o-TransaminaseCatalysed Reactions 74

    2.5 Asymmetric Synthesis of L-3-Hydroxyadamantylglycine UsingBranched Chain Aminotransferase 79

    2.6 Asymmetric Reduction of Aryl Imines Using Candidaparapsilosis ATCC 7330 83

    3 Enoate Reductases for Reduction of Electron DeficientAlkenes 87

    3.1 Asymmetric Bioreduction of Activated Alkenes UsingEne-Reductases from the Old Yellow Enzyme Family 87

    3.2 Efficient Baker s Yeast Mediated Reduction with SubstrateFeeding Product Removal (SFPR) Technology: Synthesis of(S)-2-Alkoxy-3-Aryl-1-Propanols 96

    3.3 Asymmetric Reduction of (4S)-(+)-Carvone Catalyzed by EnoateReductases (ERs) Expressed by Non-Conventional Yeast (NCY) WholeCells 100

    3.4 Preparation of Enantiomerically Pure Citronellal EnantiomersUsing Alkene Reductases 104

    3.5 Highly Enantiomeric Hydrogenation of C-C Double Bondof Methylated N-Phenyl and N-Phenylalkylmaleimides by Aspergillus fumigatus 108

    4 Industrial Carbonyl Reduction 115

    4.1 Bioreduction Using Immobilized Carbonyl Reductase Technology116

    4.2 Preparative Ketoreductase-Catalyzed Kinetic Resolution of aRacemic Aldehyde 118

    4.3 Enzymatic Reduction of 2,6-dichloro-3-fluoro-acetophenone toProduce (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol 121

    4.4 Preparative Scale Production of Poorly Soluble ChiralAlcohol Intermediate for Montelukast 124

    5 Regio- and Stereoselective Hydroxylation 129

    5.1 Engineering of an Amycolatopsis orientalis P450Compactin Hydroxylase into a Pravastatin Synthase by Changing theStereospecificity of the Enzyme 130

    5.2 Recombinant Human Cytochrome P450 Enzymes Expressed in Escherichia coli as Whole Cell Biocatalysts: PreparativeSynthesis of Oxidized Metabolites of an mGlu5 Receptor Antagonist138

    5.3 Alpha-Keto Biooxidation Using Cunninghamella echinulata (DSM63356) 147

    5.4 Aromatic Hydroxylation: Preparation of3,4-Dihydroxyphenylacetic Acid 150

    5.5 Regioselective Aromatic Hydroxylation of Quinaldine UsingLiving Pseudomonas putida Cells Containing Quinaldine4-Oxidase 153

    5.6 Regioselective Preparation of 5-Hydroxypropranolol with aFungal Peroxygenase 158

    5.7 Microbial Conversion of b-Myrcene to Geraniol by a Strain of Rhodococcus 159

    6 Oxidation of Alcohols 163

    6.1 Preparative Method for the Enzymatic Synthesis of5-Ketogluconic Acid and its Isolation 163

    6.2 Selective Enzymatic Oxidation of Atropisomeric Diaryl Ethersby Oxidation with Oxygen and Catalytic Galactose Oxidase M3-5166

    6.3 Kinetic Resolution of Chiral Secondary Alcohols by Oxidationwith Oxygen and Catalytic Galactose Oxidase M3-5 169

    6.4 ADH Catalyzed Oxidation of Sec-Alcohols Using MolecularOxygen 172

    6.5 Irreversible Non-Enantioselective Oxidation of SecondaryAlcohols Using Sphingobium ADH and Chloroacetone as Oxidant175

    6.6 Chemoselective Oxidation of Primary Alcohols to Aldehydes177

    7 Selective Oxidation 181

    7.1 Enantioselective Biocatalytic Oxidative Desymmetrization ofSubstituted Pyrrolidines 182

    7.2 Large Scale Baeyer-Villiger Monooxygenase-CatalyzedConversion of (R,S)-3-phenylbuta