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Produktbild: Pharmaceutical Emulsions

Pharmaceutical Emulsions A Drug Developer's Toolbag

162,99 €

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

14.10.2013

Herausgeber

Dipak Kumar Sarker

Verlag

John Wiley & Sons

Seitenzahl

206

Maße (L/B/H)

25,1/17/1,5 cm

Gewicht

454 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-97683-8

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

14.10.2013

Herausgeber

Dipak Kumar Sarker

Verlag

John Wiley & Sons

Seitenzahl

206

Maße (L/B/H)

25,1/17/1,5 cm

Gewicht

454 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-97683-8

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Pharmaceutical Emulsions
  • Mathematical symbols (with normal units) xi
     
    Acronyms and abbreviations xiii
     
    Preface xv
     
    Acknowledgements xvii
     
    About the companion website xix
     
    I Product considerations: medicinal formulations 1
     
    1 Historical perspective 5
     
    1.1 Landmarks 5
     
    1.2 Significant discoveries 7
     
    1.3 Difficulties 8
     
    1.4 Traditional uses 10
     
    1.5 Product regulation 13
     
    2 What is an emulsion? 15
     
    2.1 States of matter 24
     
    2.2 Summary thermodynamics 34
     
    2.3 Interfacial tension and wetting 36
     
    2.4 Shear and size reduction 46
     
    2.5 Raw materials 47
     
    3 Stability, metastability and instability 49
     
    3.1 Stokes' law 51
     
    3.2 Derjaguin-Landau-Verwey-Overbeek (DLVO) theory 52
     
    3.3 Interfacial rheology 56
     
    4 Manufacture 63
     
    4.1 Premixing 63
     
    4.2 High-shear mixers and size reduction 64
     
    4.3 Multiple and microemulsions 65
     
    4.4 Hot melt (steriles) 65
     
    4.5 Filling 66
     
    II Forms, uses and applications: biopharmaceutics 67
     
    5 Creams and ointments 69
     
    5.1 Nutraceuticals and cosmeceuticals 71
     
    5.2 Medicinals 71
     
    6 Pastes and bases 77
     
    6.1 Emolliency 77
     
    6.2 Suppositories 78
     
    6.3 Pessaries 79
     
    7 IV colloids 81
     
    7.1 Needle free 86
     
    7.2 Ocular therapy 87
     
    7.3 Cancer 88
     
    7.4 Antimicrobials 90
     
    7.5 Temperature-sensitive matrices and release forms 93
     
    7.6 Targeted endosomal use 94
     
    7.7 Solid lipid nanoparticles 95
     
    7.8 Diagnostic emulsions 98
     
    8 Transdermal patches: semisolids 99
     
    8.1 Hormones 104
     
    8.2 Analgesia 104
     
    8.3 Anaesthesia 104
     
    8.4 Nicotine 105
     
    8.5 Inserts: vaginal rings 105
     
    9 Gels 107
     
    9.1 Micro- and nanogels 107
     
    9.2 Semisolids 107
     
    10 Implants 109
     
    10.1 Plastics and glasses 109
     
    10.2 Thermoresponsive materials 110
     
    11 De novo science, sustainable novel products and platform applications 111
     
    11.1 Tablets 113
     
    11.2 Metered-dose inhalers 113
     
    11.3 Blood substitutes 114
     
    III Tests: chemistry to control the quality, efficacy and fitness for purpose of a product 117
     
    12 Physicochemical properties 119
     
    12.1 Thermal evaluation (differential scanning calorimetry) and lipid polymorphs 124
     
    12.2 Drug form, log P and Lipinski rules 129
     
    12.3 Skin and epithelial models 133
     
    12.4 Drug delivery routes 134
     
    13 Sizing and microscopy 137
     
    13.1 zeta -potential 137
     
    13.2 Hydrodynamic diameter 139
     
    14 Rheology, texture, consistency and spreadability 141
     
    14.1 Bulk properties 141
     
    14.2 Solid-state and nanorheological properties 144
     
    14.3 Interfacial properties 144
     
    15 Quality control, process analytical technology and accelerated testing 149
     
    15.1 Preformulation, high-throughput screening 150
     
    15.2 Industrial concerns 151
     
    15.3 Rancimat and other methods 152
     
    Questions 155
     
    Guide for readers 155
     
    Specimen 'test' questions 155
     
    Answers 168
     
    References 173
     
    Index 181