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  • Produktbild: Structure and Function of the Gonadotropins
  • Produktbild: Structure and Function of the Gonadotropins

Structure and Function of the Gonadotropins

Aus der Reihe Biochemical Endocrinology

97,99 €

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

27.08.2012

Herausgeber

Kenneth W. McKerns

Verlag

Springer Us

Seitenzahl

630

Maße (L/B/H)

22,9/15,2/3,5 cm

Gewicht

929 g

Auflage

1978

Sprache

Englisch

ISBN

978-1-4684-3416-3

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

27.08.2012

Herausgeber

Kenneth W. McKerns

Verlag

Springer Us

Seitenzahl

630

Maße (L/B/H)

22,9/15,2/3,5 cm

Gewicht

929 g

Auflage

1978

Sprache

Englisch

ISBN

978-1-4684-3416-3

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: GPSR Kontakt

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  • Produktbild: Structure and Function of the Gonadotropins
  • Produktbild: Structure and Function of the Gonadotropins
  • 1 Mechanism of Action of Gonadoptropins and the Regulation of Gene Expression.- 1. Introduction.- 2. Development of the cAMP–Protein Kinase System in the Neonatal Rat Ovary.- 3. Cyclic-AMP-Dependent Ovarian Nuclear Protein Kinase.- 4. Nuclear Translocation of Ovarian Cytoplasmic cAMP-Dependent Protein Kinase—Mechanism of Translocation.- 5. Functional Importance of Protein Kinase Translocation.- 6. Correlation between Gonadotropin Action and Ovarian Nuclear Activity.- 7. Conclusion.- Discussion.- References.- 2 Chemical Approaches to the Structure-Function Relationships of Luteinizing Hormone (Lutropin).- 3 Structural and lmmunochemical Properties of Human Choriogonadotropin.- 1. Introduction.- 2. Purification.- 3. Structure.- 4. Carbohydrate Function.- 5. Synthesis.- 6. Immunochemistry and Immunoassay.- 7. Biological Activities Present in “Crude” and “Purified” hCG.- Discussion.- References.- 4.Glycoprotein Hormones: Some Aspects of Studies of Secondary and Tertiary Structure.- 1. Introduction.- 2. Disulfide Bonds.- 3. Circular Dichroism Spectra.- Discussion.- References.- 5 Autoradiographic Localization of FSH-Binding Sites on Sertoli Cells and Spermatogonia in Testes from Hypophysectomized Rats.- 1. Introduction.- 2. Experimental Methods.- 3. Results.- 4. Comments.- Discussion.- References.- 6 Serum-Factor- and Prolactin-Induced Stimulation of DNA Synthesis by Nuclei Externalized from Mammary Tissue.- 1 Introduction.- 2. Methods.- 3. Results.- 4. Discussion.- Discussion.- References.- 7 Target Cell Prolactin.- 1. Rationale.- 2. Materials and Methods.- 3. Endogenous Prolactin in Milk and inside Active Milk-Secretory Cells of the Midlactational, Pup-Deprived Rat.- 4. Endogenous Prolactin in Ovaries and in Adrenal and Mammary Glands of the Midlactational, Non-Pup-Deprived Rat.- 5. Studies of Mammary Glands and Corpora Lutea of Estrogen-Treated Postpartum Rats.- 6. Endogenous Prolactin in Prolactin Target Tissues of the Male Rat.- 7. Binding Sites for Homologous Exogenous Prolactin in Male and Female Prolactin Target Tissues—Comparisons with the Presence of Endogenous Prolactin in These Tissues.- 8. Conclusion.- Discussion.- References.- 8 The Structure and Function of Follicle-Stimulating Hormone.- 1. Introduction.- 2. Human Pituitary FSH.- 3. Equine Pituitary FSH.- 4. Ovine Pituitary FSH.- 5. Pituitary FSH from Other Sources.- 6. Urinary FSH.- 7. Function of FSH.- Discussion.- References.- 9 The Biosynthesis of Prolactin.- 1. Introduction.- 2. Cell-Free Translation of Prolactin Messenger RNA.- 3. Regulation of Prolactin Synthesis.- 4. Estrogenic Regulation of Preprolactin Messenger RNA Levels.- 5. Summary.- Discussion.- References.- 10 The Biosynthesis of Chorionic Gonadotropin and Placental Lactogen in First- and Third-Trimester Human Placenta.- 1. Introduction.- 2. Methods.- 3. Results.- 4. Discussion.- 5. Future Projections.- Discussion.- References.- 11 The Interaction of Follitropin (FSH) with Membrane-Bound and Solubilized Gonadal Receptors and Adenylate Cyclase.- 1. Interaction of Follitropin with Receptors in Rat Testis.- 2. Interaction of Follitropin with Ovarian Receptors.- 3. Interaction of Follitropin with Receptors in Bovine Testis.- 4. Solubilization of the Follitropin Receptor.- 5. Some Characteristics of the Solubilized Receptor and Properties of Its Interaction with Follitropin.- 6. Interaction of Follitropin with Testicular Adenylate Cyclase.- 7. Factors That Affect Interaction (in Vitro) of Follitropin with Receptor and Stimulation of Adenylate Cyclase.- 8. Inhibitors of Follitropin Binding to Gonadal Receptors.- References.- 12 Drug Effects on Lutropin Action.- 1. Introduction.- 2. Inhibition of Lutropin Action by Antimalarial Drugs.- 3. Prostaglandins and Lutropin Action.- 4. Effect of 1-Methyl-3-isobutyl Xanthine on Lutropin Action 288.- 5. Concluding Remarks.- Discussion.- References.- 13 Effects of FSH and LH on RNA Synthesis in the Testis: Role of Ornithine Decarboxylase.- 14 Regulation of Gene Expression in the Nucleus by Gonadotropins.- 15 Glycoprotein Hormones and Their Subunits— Immunological and Biological Characterization.- 1. Introduction.- 2. Immunological Behavior.- 3. Forms of Glycoprotein Hormones in Tissues and Fluids.- 4. Abnormal Human Chorionic Gonadotropin Production.- 5. Ubiquity of Human Chorionic Gonadotropin.- Discussion.- References.- 16 Biochemical and Biological Properties of Fish Gonadotropins and Their Subunits: Comparison with Mammalian Hormones.- 1. Introduction.- 2. Purification and Biological Properties of Fish Gonadotropins.- 3. Biochemistry of Fish Gonadotropins and Their Subunits.- 4. Conclusions.- References.- 17 Molecular Aspects of the Subunit Assembly of Glycoprotein Hormones.- 1. Introduction.- 2. Three-Dimensional Features of the Active Conformation of Glycoprotein Hormones.- 3. Assessment of the Conformational Changes Induced by the Assembly of the Subunits.- 4. Kinetic Mechanism of Subunit Assembly.- 5. Subunit Assembly: A Biological Mechanism for Controlling the Active State of the Hormone?.- References.- 18 Biological and Immunological Distinctions between Pituitary and Serum LH in the Rat.- 1. Introduction.- 2. Methods.- 3. Findings and Interpretations.- 4. Discussion.- Discussion.- References.- 19 Parallels in the Modes of Action of Peptide and Steroid Hormones: Membrane Effects and Cellular Entry.- 1. Introduction and Conceptual Framework.- 2. Cellular Entry of Peptide Hormones.- 3. Membrane Recycling and Vesicular Flow.- 4. Lysosomal Compartmentation of Receptor.- 5. Receptor Transport to the Plasmalemma: Postulated Correlation with Lysosome Activation.- 6. Autoregulation of Receptor Biosynthesis and Translocation.- 7. Nuclear Accumulation—Common to Hormone Classes.- 8. Prospectus and Concluding Remarks.- Discussion.- References.- 20 Timing and Sites of Testicular Effects of FSH in Vivo.- 1. Introduction.- 2. Effects of FSH in the Immature Testis.- 3. Adult Testis.- 4. Summary and Conclusions.- Discussion.- References.- 21 Leydig-Cell Responsiveness to LH-Hcg Stimulation: Mechanisms of hCG- and Steroid-Induced Refractoriness.- 1. Introduction.- 2. In Vivo Desensitization to Human Chorionic Gonadotropin.- 3. Variations in the Number of Receptors for Human Chorionic Gonadotropin during Desensitization and Recovery: Down-Regulation.- 4. Mechanism of Down-Regulation.- 5. Leydig-Cell Responsiveness to Human Chorionic Gonadotropin and Dibutyryl Cyclic AMP in Vitro during the Desensitization Period.- 6. Desensitization in Hypophysectomized Animals.- 7. Corticoid-Induced Refractoriness.- 8. Estrogen-Induced Refractoriness.- 9. Discussion.- References.- 22 FSH and the Sertoli Cell.- 1. Introduction.- 2. FSH Binding in the Testis.- 3. Stimulation of Cyclic AMP by FSH.- 4. Androgens and the Function of the Sertoli Cell.- 5. Androgen-Binding Protein; A Sertoli-Cell Product under Hormonal Control.- 6. Role of the Sertoli Cell in FSH Feedback Regulation.- 7. Concluding Comments.- References.- 23 Immunocytochemical Demonstration of Endogenous Membrane and Intracellular Gonadotropin-Binding Sites in the Fetal Rat Testis.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Dis­cussion.- 5. Summary and Conclusions.- References.- 24 Gonadotropin-Target Cell Interactions: A Model Based on Morphological Localization.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- References.- 25 Localization of Human Chorionic Gonadotropin in Lysosomes of Ovine Luteal Cells.- 1. Introduction.- 2. Materials and Methods.- 3. Results and Discussion.- 4. Conclusions.- Discussion of Chapters 23–25.- References.