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Produktbild: Blood Cell Biochemistry Volume 3
Band 3

Blood Cell Biochemistry Volume 3 Lymphocytes and Granulocytes

Aus der Reihe Blood Cell Biochemistry

49,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

31.10.2012

Herausgeber

J. Robin Harris

Verlag

Springer Us

Seitenzahl

413

Maße (L/B/H)

25,4/17,8/2,4 cm

Gewicht

815 g

Auflage

Softcover reprint of the original 1st ed. 1991

Sprache

Englisch

ISBN

978-1-4613-6692-8

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

31.10.2012

Herausgeber

J. Robin Harris

Verlag

Springer Us

Seitenzahl

413

Maße (L/B/H)

25,4/17,8/2,4 cm

Gewicht

815 g

Auflage

Softcover reprint of the original 1st ed. 1991

Sprache

Englisch

ISBN

978-1-4613-6692-8

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: ProductSafety@springernature.com

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  • Produktbild: Blood Cell Biochemistry Volume 3
  • 1 Biochemical, Immunological, and Molecular Markers of Hemopoietic Precursor Cells.- 1. Introduction.- 2. Biochemical Markers.- 2.1. Terminal Deoxynucleotide Transferase.- 2.2. Enzymes in Nucleotide Metabolism.- 3. Immunological Markers.- 4. Molecular Markers.- 5. Analysis of Human Hemopoietic Ontogenesis by Immunological and Molecular Markers.- 6. New Opportunities for Immunological and Molecular Markers: Minimal Residual Disease Detection and Therapeutical Approaches.- 7. References.- 2 Cell Surface Markers in Leukemia and Lymphoma.- 1. Introduction.- 2. B Cells.- 2.1. Normal B-Cell Ontogeny.- 2.2. B-Cell Leukemias and Lymphomas.- 3. T Cells.- 3.1. Normal T-Cell Ontogeny.- 3.2. T-Cell Leukemias and Lymphomas.- 4. Myeloid Cells.- 4.1. Normal Myeloid Ontogeny.- 4.2. Myeloid Leukemias.- 5. Summary.- 6. References.- 3 Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts.- 1. Introduction.- 2. Microfilaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 2.1. Actin and Actin-Associated Proteins in Nonmuscle Cells.- 2.2. Actin Isoforms.- 2.3. Organization of Actin in Normal Lymphocytes.- 2.4. Interactions between Actin and Surface Antigens in Lymphocytes.- 2.5. Actin in Leukemic Lymphocytes and Lymphoblasts.- 3. Intermediate-Size Filaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 3.1. The Intermediate Filament System.- 3.2. Distribution of Vimentin in Lymphocytes in Normal Conditions.- 3.3. Vimentin in Neoplastic Lymphocytes and Lymphoblasts.- 3.4. Expression of Cytokeratin in Lymphoid Tissues.- 4. Microtubules in Lymphoid Cells.- 5. Organization of Spectrin in Lymphocytes.- 6. Conclusions.- 7. References.- 4 Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation.- 1. Introduction.- 2. B-Cell Antigen Receptor-Mediated Signaling.- 3. Molecular Bases of T-Cell-Mediated B-Cell Signaling.- 4. Biological Evidence for Ia-Mediated Signal Transduction.- 5. Biochemical Evidence for Ia-Mediated Signal Transduction.- 6. Conclusions.- 7. References.- 5 IgE Receptors on Lymphocytes and IgE-Binding Factors.- 1. Introduction.- 2. Historical Overview.- 3. Fc?RII on Lymphocytes.- 3.1. Fc?RII-Bearing Cells.- 3.2. Function of Fc?RII.- 3.3. Molecular Properties of Fc?RII.- 3.4. Regulation of Fc?RII Expression on Lymphocytes.- 4. IgE-Binding Factors.- 4.1. Rat.- 4.2. Murine.- 4.3. Human.- 5. Glycosylation-Regulating Factors: GEF and GIF.- 5.1. Rat.- 5.2. Murine.- 6. Interleukin 4 and Gamma Interferon.- 7. CD23 Antigen.- 8. Conclusion.- 9. References.- 6 Lymphocyte-Mediated Cytolysis: Role of Granule Mediators.- 1. Role of Granules and Perform in Lymphocyte-Mediated Killing.- 1.1. The Granule Exocytosis or Secretion Model for Cell Killing.- 1.2. Cytoplasmic Granules and Perform as Mediators of Cytotoxicity.- 1.3. A Family of Serine Esterases Localized in Lymphocyte Granules.- 1.4. Proteoglycans.- 1.5. Leukalexins and Cytokines Related to Tumor Necrosis Factor and Lymphotoxin.- 2. Other Candidate Mechanisms of Lymphocyte-Mediated Killing.- 3. Resistance of Lymphocytes to Self-Mediated Killing.- 4. Conclusion.- 5. References.- 7 CR1—Cytoskeleton Interactions in Neutrophils.- 1. Introduction.- 2. Detergent Extraction of Cells.- 3. Receptor—Cytoskeleton Interactions.- 4. The C3b Receptor (CR1).- 5. References.- 8 The Flow of Granular Organelles in Leukocyte Differentiation.- 1. Introduction.- 2. Biogenesis of Membrane-Bound Organelles.- 2.1. Introduction.- 2.2. Endoplasmic Reticulum.- 2.3. Golgi Complex.- 2.4. Lysosomes.- 2.5. Communication between Compartments: Endosomes.- 2.6. Secretory Granules.- 3. Leukocyte Granules are Major Determinants of Function.- 3.1. Neutrophils.- 3.2. Platelets.- 3.3. Cytotoxic Lymphocytes.- 4. Granules Interact with the Plasma Membrane.- 4.1. Neutrophils.- 4.2. Platelets.- 5. Pathology of Myeloid Granules and Plasma Membranes.- 5.1. Nonneoplastic.- 5.2. Leukemic.- 6. Conclusion.- 7. References.- 9 The Elusive Oxidase: The Respiratory Burst Oxidase of Human Phagocytes.- 1. Introduction.- 2. The Respiratory Burst.- 2.1. General Description.- 2.2. Oxygen Radical Species Produced in the Respiratory Burst.- 3. The Activated NADPH Oxidase.- 3.1. Subcellular Localization of the Oxidase.- 3.2. Stoichiometry and Cofactor Requirements of the Active Oxidase.- 4. Identification of Components of the Oxidase.- 4.1. Attempts to Isolate the NADPH Oxidase from Stimulated Cells.- 4.2. Activation of the Oxidase in Resting Phagocyte Membranes in a Cell-Free System.- 5. Postulated Components of the NADPH Oxidase.- 5.1. A Membrane-Associated Cytochrome b.- 5.2. A 47-kDa Phosphoprotein.- 5.3. A Cytosolic 65-kDa Flavoprotein.- 5.4. Cytosolic Nucleotide-Binding Proteins.- 5.5. Other Oxidase Components or Cofactors.- 6. Summary.- 7. References.- 10 Myeloperoxidase: Localization, Structure, and Function.- 1. Introduction.- 2. Background.- 3. Structure.- 4. Synthesis.- 4.1. Biosynthesis, Glycosylation, Further Processing, and Intracellular Transport.- 4.2. Biosynthesis of the Herne Prosthetic Group.- 5. Molecular Biology: The Myeloperoxidase Gene.- 6. Function.- 6.1. Mechanism of Action of the Myeloperoxidase System.- 6.2. The Myeloperoxidase-Mediated Antimicrobial System.- 6.3. Extracellular Effects of the Myeloperoxidase System.- 7. References.- 11 Mechanisms of Oxidase Activation in Neutrophils: Importance of Intracellular Calcium and Cytoskeletal Interactions.- 1. Importance of the Neutrophil Oxidase in Physiology and Pathology.- 1.1. Overview.- 1.2. Appropriate and Inappropriate Oxidase Activation.- 2. The Neutrophil Oxidase.- 2.1. Molecular Properties.- 2.2. Subcellular Location.- 2.3. Superoxide Production.- 3. Stimulus—Oxidase Activation Coupling.- 3.1. Role of Calcium.- 3.2. Role of Protein Kinases.- 3.3. Role of Phospholipid-Derived Messengers.- 3.4. Role of Other Intracellular Messengers.- 3.5. Priming.- 4. Cytoskeletal Components and Neutrophil Activity.- 4.1. Microfilaments.- 4.2. Microtubules.- 4.3. Intermediate Filaments.- 4.4. Microtrabeculae.- 4.5. Interaction between Cytoskeletal Components.- 5. Actin Polymerization and Oxidase Activation.- 5.1. Characteristics of Actin Polymerization Accompanying Oxidase Activation.- 5.2. Interaction of Actin Polymerization with Oxidase Activation.- 5.3. Actin Polymerization and Ca2+ Homeostasis.- 5.4. Intracellular Triggers for Actin Polymerization.- 6. Conclusion.- 7. References.- 12 Neutrophil and Eosinophil Granules as Stores of “Defense” Proteins.- 1. Introduction.- 2. The Vacuolar Apparatus of Granulocytes.- 2.1. Neutrophils.- 2.2. Eosinophils.- 3. Defense Polypeptides of Granulocytes.- 3.1. Bactericidal/Permeability-Increasing Protein.- 3.2. Cationic Antimicrobial Proteins 57 and 37.- 3.3. Cathepsin G.- 3.4. Defensins.- 3.5. Bactenecins.- 3.6. Eosinophil Major Basic Protein.- 3.7. Eosinophil Cationic Protein.- 4. Conclusions.- 5. References.- 13 Membrane Glycoproteins of Mast Cells and Basophils.- 1. Introduction.- 2. Receptors for Complement Anaphylatoxins on Mast Cells and Basophils.- 2.1. The Anaphylatoxins.- 2.2. Characterization of Anaphylatoxin Receptors.- 3. Immunoglobulin Receptors on Mast Cells and Basophils.- 3.1. Fc?R1, the High-Affinity Receptor for IgE Fc.- 3.2. Molecular Cloning of Fc?R1 Subunits.- 3.3. Mast Cell and Basophil Receptors for IgE Fc.- 4 Immunoglobulin E on Mast Cells and Basophils.- 4.1. Interaction of IgE Fc with Mast Cells and Basophils.- 4.2. Structure and Biochemistry of IgE.- 4.3. Conformation of Receptor-Bound IgE.- 4.4. Molecular Cloning of ?.- 5. Hemopoietic Lineage-Associated Membrane Glycoproteins of Mast Cells and Basophils.- 5.1. Serologically Defined Membrane Glycoproteins.- 5.2. Receptors for Hemopoietic Growth Factors.- 5.3. Cytoadhesive Glycoproteins of Mast Cells.- 6. References.