The Chemical Biology of Nucleic Acids
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Sprache:Englisch
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Produktdetails
Format
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Nein
Erscheinungsdatum
22.04.2010
Verlag
John Wiley & Sons IncSeitenzahl
478 (Printausgabe)
Dateigröße
13610 KB
Auflage
1. Auflage
Sprache
Englisch
EAN
9780470664018
With extensive coverage of synthesis techniques and applications,
this text describes chemical biology techniques which have gained
significant impetus during the last five years. It focuses on the
methods for obtaining modified and native nucleic acids, and their
biological applications. Topics covered include:
* chemical synthesis
of modified RNA
* expansion of the genetic alphabet in nucleic acids by creating
new base pairs
* chemical biology of DNA replication: probing DNA polymerase
selectivity mechanisms with modified nucleotides
* nucleic-acid-templated chemistry
* chemical biology of peptide nucleic acids (PNA)
* the interactions of small molecules with DNA and RNA
* the architectural modules of folded RNAs
* genesis and biological applications of locked nucleic acid
(LNA)
* small non-coding RNA in bacteria
* microRNA-guided gene silencing
* nucleic acids based therapies
* innate immune recognition of nucleic acid
* light-responsive nucleic acids for the spatiotemporal control
of biological processes
* DNA methylation
* frameworks for programming RNA devices
* RNA as a catalyst: The Diels-Alderase-Ribozyme
* evolving an understanding of RNA function by in vitro
approaches
* the chemical biology of aptamers: synthesis and
applications
* nucleic acids as detection tools
* bacterial riboswitch discovery and analysis
The Chemical Biology of Nucleic Acids is an
essential compendium of the synthesis of nucleic acids and
their biological applications for bioorganic chemists, chemical
biologists, medicinal chemists, cell biologists, and molecular
biologists.
this text describes chemical biology techniques which have gained
significant impetus during the last five years. It focuses on the
methods for obtaining modified and native nucleic acids, and their
biological applications. Topics covered include:
* chemical synthesis
of modified RNA
* expansion of the genetic alphabet in nucleic acids by creating
new base pairs
* chemical biology of DNA replication: probing DNA polymerase
selectivity mechanisms with modified nucleotides
* nucleic-acid-templated chemistry
* chemical biology of peptide nucleic acids (PNA)
* the interactions of small molecules with DNA and RNA
* the architectural modules of folded RNAs
* genesis and biological applications of locked nucleic acid
(LNA)
* small non-coding RNA in bacteria
* microRNA-guided gene silencing
* nucleic acids based therapies
* innate immune recognition of nucleic acid
* light-responsive nucleic acids for the spatiotemporal control
of biological processes
* DNA methylation
* frameworks for programming RNA devices
* RNA as a catalyst: The Diels-Alderase-Ribozyme
* evolving an understanding of RNA function by in vitro
approaches
* the chemical biology of aptamers: synthesis and
applications
* nucleic acids as detection tools
* bacterial riboswitch discovery and analysis
The Chemical Biology of Nucleic Acids is an
essential compendium of the synthesis of nucleic acids and
their biological applications for bioorganic chemists, chemical
biologists, medicinal chemists, cell biologists, and molecular
biologists.
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