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Produktbild: Mycobacterium tuberculosis

Mycobacterium tuberculosis Interactions with the Immune System

Aus der Reihe Infectious Agents and Pathogenesis

97,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

29.03.2012

Herausgeber

Mauro Bendinelli + weitere

Verlag

Springer Us

Seitenzahl

448

Maße (L/B/H)

22,9/15,2/2,5 cm

Gewicht

650 g

Auflage

Softcover reprint of the original 1st ed. 1988

Sprache

Englisch

ISBN

978-1-4684-5420-8

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

29.03.2012

Herausgeber

Verlag

Springer Us

Seitenzahl

448

Maße (L/B/H)

22,9/15,2/2,5 cm

Gewicht

650 g

Auflage

Softcover reprint of the original 1st ed. 1988

Sprache

Englisch

ISBN

978-1-4684-5420-8

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Mycobacterium tuberculosis
  • 1. Mycobacterial Antigens: Reagents for Tuberculin Skin Testingand Serodiagnosisof Tuberculosis.- 1. Introduction.- 2. Culture Filtrate and Bacillary Extracts as Source Materials for Tuberculin Preparation.- 3. Earlier Studies on the Preparation of Tuberculins for Skin Testing.- 4. Survey of Other Fractionation Modalities for Separating and Purifying Mycobacterial Antigens.- 5. Serologic Methods for Diagnosis of Tuberculosis.- 6. Molecular Biologic Approaches for Examining Antigens from M. tuberculosis.- References.- 2. Role of Adjuvant and Immunogenic Moieties of M. tuberculosis in Pathogenicity.- 1. Introduction.- 2. Role of Adjuvant Moieties of M. tuberculosis.- 3. Role of the Immunogenic Moieties of M. tuberculosis.- 4. Summary.- References.- 3. Genetic Background of the Host andExpression of NaturalResistance and AcquiredImmunity to M. tuberculosis.- 1. Introduction.- 2. Inherited Resistance to Tuberculosis in Rabbits.- 3. Genetic Control of Tuberculosis and BCG Infection in the Mouse.- 4. Genetic Control of Tuberculosis in Humans.- 5. Conclusions.- References.- 4. Immune Response to Mycobacteria: Characterization ofImmunocompetent Cells inTuberculous Lesions of Humans.- 1. The First Contagion: The Alveolar Macrophages Represent the First-line Defense in Deep Lung.- 2. Immunity in Tuberculosis is Cell Mediated.- 3. T Lymphocytes Activate Alveolar Macrophages for Killing Tubercle Bacilli.- 4. In Vitro Model of Human Tuberculoimmunity.- 5. Lymphokines and PPD Responsiveness.- 6. The Tuberculous Lesion in Humans: Characterization of the Immunocompetent Cells.- 7. Perspectives and Conclusion.- References.- 5. The Tubercle Bacillus—Human Macrophage Relationship Studied In Vitro.- 1. The Cellular Focus of Tuberculosis.- 2. The Model and the Data It Produces.- 3. Macrophage Uptake of Tubercle Bacilli.- 4. Nature of Bacillary Growth in Cultured Human Monocytic Phagocytes.- 5. Morphology of the Tubercle Bacillus-Human Monocytic Phagocyte Relationship by Optical Microscopy.- 6. Morphology of the Tubercle Bacillus—Human Monocytic Phagocyte Relationship by Electron Microscopy.- 7. Synopsis of the Tubercle Bacillus-Human Monocytic Phagocyte Macrophage Relationship as Revealed by the in Vitro Model.- References.- 6. Regulation and Pharmacology of GranulomatousInflammation.- 1. Introduction.- 2. Murine Schistosomiasis as a Model of Granulomatous Inflammation.- 3. Granulomatous Inflammation Induced by Killed BCG or by BCG Cell Walls.- 4. Genetic Control of Host Resistance to BCG.- 5. Pharmacologic Control of Granulomatous Inflammation.- 6. Summary.- References.- 7. Cytolytic T Cells in M. tuberculosisInfections.- 1. Introduction.- 2. Results.- 3. Discussion.- 4. Concluding Remarks.- References.- 8. Anergy and Other Immunologic Perturbances in Mycobacterial Infections: Overview.- 1. Introduction.- 2. The Immune Spectrum in Human Mycobacterial Diseases.- 3. The Immune Spectrum in Experimental Mycobacterial Infections.- 4. Conclusions.- References.- 9. Anergy in Experimental Mouse Models of MycobacterialInfection.- 1. Introduction.- 2. Manifestations of Anergy in Vitro.- 3. Possible Mechanisms Underlying Unresponsiveness in Vitro.- 4. Manifestations of Anergy in Vivo.- 5. Unresponsiveness to Unrelated Antigens.- 6. Conclusions.- References.- 10. Suppressor Cells in Mycobacterial Infections.- 1. Introduction.- 2. Suppressor Cells Induced by Mycobacterial Infection.- 3. Cell—Cell Interactions Responsible for Ts-Cell Induction.- 4. Mechanisms Underlying the Suppression Induced by Mycobacterial Infection.- 5. Future Prospect.- References.- 11. Immunoregulatory Function ofMononuclear Phagocytes inTuberculosis.- 1. Introduction.- 2. Immune Induction and Effector Functions of Mononuclear Phagocytes.- 3. Immunosuppression by Mononuclear Phagocytes.- 4. Immunosuppressive Mycobacterial Products.- 5. Immunosuppression by Adherent Mononuclear Cells in Tuberculosis.- 6. Adherent Mononuclear Cell Subpopulations Responsible for Suppression.- 7. Cellular Properties Associated with Immunosuppression.- 8. Mediators of Immunosuppression in Tuberculosis.- 9. Discussion.- References.- 12. Role of B Lymphocytes and Antibodies in the Regulation ofCell-Mediated ImmuneReactions to BCG in Mice.- 1. Introduction.- 2. Immunoregulatory Role of B Lymphocytes and/or Antibodies in Nonmycobacterial Model Systems.- 3. Regulation of Delayed-Type Hypersensitivity to BCG in Mice.- 4. Regulation of the Granulomatous Response to BCG in Mice.- 5. Conclusion.- References.- 13. Polyclonal Lymphocyte Activation by M. tuberculosis and Its Products.- 1. Introduction.- 2. Tuberculin: A Polyclonal B-Cell Activator.- 3. Mycobacterium bovis.- 4. Muramyl Dipeptides.- 5. Various Mycobacterial Components.- 6. Summary and Conclusions.- References.- 14. Mechanisms of Toxicity of TubercleBacilli for Macrophages.- 1. Historical Background.- 2. Evidence that Virulent Mycobacteria Are Toxic for Macrophages.- 3. Evidence that Virulent Tubercle Bacilli Can Interfere with Lysosome—Phagosome Fusion.- 4. Disruption of the Phagosomal Membrane by the Virulent H37Rv Strain of M. tuberculosis.- 5. Resistance of BCG-Immune AM to Phagosome Destruction by the H37Rv Strain.- 6. Effect of Isonicotinic Acid Hydrazide (INH) on the Phagosome Destruction Potential of the H37Rv Strain.- 7. Attempts to Demonstrate Phagosome Destruction Utilizing Latex Beads Coated with Trehalose Dimycolate and Sulfolipids.- 8. Evaluation of Putative Virulence Factors of Mycobacteria Expressed in Normal Alveolar Macrophages.- 9. Summation and Perspectives.- References.- 15. Mycobacterium-Induced Suppressor Cells and Their ClinicalImportance.- 1. Introduction.- 2. Experimental Induction of Suppressor Cells.- 3. Clinical Observations.- References.- 16. The Protective Effects of BCG Vaccination againstTuberculosis.- 1. Introduction.- 2. Key Events in the Pathogenesis of Tuberculosis.- 3. Effect of BCG on Tuberculosis in Humans.- 4. Effect of BCG on Tuberculosis in Animal Models.- 5. Concluding Remarks.- References.- 17. Changing Faces of Clinical Tuberculosis.- 1. Introduction.- 2. Epidemiology of Disease.- 3. Incidence and Morbidity.- 4. Tuberculosis in Children ..- 5. Tuberculosis in Old Age.- 6. Tuberculosis in Immunocompromised Hosts.- 7. Tuberculosis in Homeless and Alcoholics.- 8. Tuberculosis in Health Care Workers.- 9. Tuberculosis among Immigrants.- 10. Clinical Presentation.- 11. Tuberculosis Therapy.- 12. Adverse Drug Reactions.- 13. Preventive Therapy.- References.- 18. Mycobacterium avium-Complex InfectionsandImmunodeficiency.- 1. Introduction.- 2. M. avium-Complex Infections in the Normal Population.- 3. M. avium-Complex Infections in Immunodepleted Patients.- 4. M. avium-Complex Infections in AIDS Patients.- 5. Conclusions.- 6. Summary.- References.