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Produktbild: Fundamentals of Intracellular Calcium

Fundamentals of Intracellular Calcium

109,99 €

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.11.2017

Verlag

John Wiley & Sons Inc

Seitenzahl

464

Maße (L/B/H)

24,9/56,9/1,3 cm

Gewicht

975 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-118-94187-4

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.11.2017

Verlag

John Wiley & Sons Inc

Seitenzahl

464

Maße (L/B/H)

24,9/56,9/1,3 cm

Gewicht

975 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-118-94187-4

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Fundamentals of Intracellular Calcium
  • About the Author xvii
     
    Preface xix
     
    List of Acronyms xxiii
     
    About the Companion Web Site xxxv
     
    1 Calcium is Special 1
     
    1.1 Calcium and Everyday Events 1
     
    1.2 Discovery of Calcium 2
     
    1.3 A Natural History of Calcium 3
     
    1.3.1 Calcium by the Sea 3
     
    1.3.2 Calcium in Your Wake-Up Call 4
     
    1.4 The Elements of Life 5
     
    1.5 Natural Occurrence of Calcium 7
     
    1.5.1 Isotopes of Calcium 7
     
    1.5.2 Geology of Calcium 7
     
    1.5.3 Calcium Outside Cells 8
     
    1.5.4 Calcium Inside Cells 10
     
    1.6 Requirement of Cells for Ca2+ 12
     
    1.6.1 Calcium in External Fluids 12
     
    1.6.2 Requirement of Cell Types for Calcium 12
     
    1.7 The Four Biological Roles of Calcium 13
     
    1.7.1 Structural 13
     
    1.7.2 Electrical across Biological Membranes 13
     
    1.7.3 Extracellular Cofactor 14
     
    1.7.4 Intracellular Regulator 14
     
    1.8 The Puzzle about Ca2+ Inside Cells 17
     
    1.9 How Important Intracellular Calcium has been in Science 18
     
    1.10 Darwin and Intracellular Ca2+ 19
     
    1.11 The Scene Set 21
     
    1.12 'Ja Kalzium, das ist alles!' 21
     
    1.13 Calcium - The Fundamentals 22
     
    Recommended Reading 23
     
    Books 23
     
    Reviews 23
     
    Articles 23
     
    2 Intracellular Calcium - Principles 25
     
    2.1 Ca2+ and the Concept of Cell Signalling 25
     
    2.1.1 Primary Signals and Intracellular Ca2+ 25
     
    2.1.2 The Source of Intracellular Ca2+ 27
     
    2.2 The Problem 29
     
    2.3 Some Key Questions 29
     
    2.3.1 Question 1 - What is the Primary Stimulus and Secondary Regulator(s)? 29
     
    2.3.2 Question 2 - What is the Intracellular Signal? 30
     
    2.3.3 Question 3 - How do the Secondary Regulators Work? 30
     
    2.4 Types of Intracellular Ca2+ Signal 31
     
    2.4.1 Category of Cell Based on the Ca2+ Signal 31
     
    2.4.2 Types of Ca2+ Signal 32
     
    2.4.3 Ca2+ Sparks, Puffs and Sparklets 33
     
    2.5 Rubicon Principle 34
     
    2.5.1 Digital Versus Analogue Cell Events 34
     
    2.5.2 The Ca2+ Signaling Toolkit 36
     
    2.5.3 Amplification Mechanisms 36
     
    2.6 Key Experiments to Answer Key Questions 38
     
    2.6.1 Raising Cytosolic Free Ca2+ Artificially 38
     
    2.6.2 Measurement of Free Ca2+ in Live Cells 38
     
    2.6.3 How the Ca2+ Signal is Generated 39
     
    2.6.4 Identifying the Ca2+ Target 39
     
    2.6.5 How Binding of Ca2+ to its Target Causes the Cell Event 39
     
    2.6.6 How the Cell Returns to Rest 40
     
    2.7 Nomenclature - How Things are Named 40
     
    2.7.1 English and Etymology 40
     
    2.7.2 Organisms 41
     
    2.7.3 Acronyms, Cells and Biochemistry 41
     
    2.7.4 Genes 42
     
    2.7.5 Proteins and Protein Sequences 43
     
    2.7.6 Enzymes 43
     
    2.7.7 Ion Channels 44
     
    2.7.8 Agonists and Antagonists 47
     
    2.7.9 Chemicals 47
     
    2.7.10 Toxins 48
     
    2.7.11 Drugs 48
     
    2.7.12 Ca2+ Indicators 49
     
    2.7.13 Units 50
     
    2.8 Model Systems 50
     
    2.9 Darwin, Wallace and Intracellular Ca2+ 51
     
    2.9.1 Natural Selection in Real Time 51
     
    2.9.2 Small Change by Small Change 52
     
    2.10 New Knowledge 54
     
    2.11 Conclusions 55
     
    Recommended reading 55
     
    Books 55
     
    Reviews 55
     
    Papers 56
     
    3 A Century plus of Intracellular Ca2+ 57
     
    3.1 Background 57
     
    3.1.1 Pathway of Discovery and Invention for Intracellular Ca2+ 57
     
    3.1.2 Model Systems 58
     
    3.2 Why Study the History of Science? 59
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