Preface xix
1 Bioactive Polysaccharides of Vegetable and Microbial Origins: An Overview 1
Giuseppina Tommonaro, Annarita Poli, Paola Di Donato, Roberto Abbamondi Gennaro, Ilaria Finore and Barbara Nicolaus
1.1 Introduction 1
1.2 Anticarcinogenic Polysaccharides 3
1.3 Anti-inflammatory/Immunostimulating Polysaccharides 8
1.4 Antiviral Polysaccharides 13
1.5 Antioxidant Polysaccharides 17
1.6 Other Biotechnological Applications 21
1.7 Conclusions and Future Perspectives 23
Acknowledgments 23
Reference 24
2 Chitosan: An Emanating Polymeric Carrier for Drug Delivery 33
Priti Girotra and Shailendra Kumar Singh
2.1 Introduction 33
2.2 Preparation of Chitosan 34
2.3 Physicochemical Properties of Chitosan 35
2.4 Biological Activities of Chitosan 36
2.5 Pharmaceutical Applications of Chitosan 39
2.6 Functionalization of Chitosan 49
2.7 Conclusion and Future Perspectives 49
Reference 51
3 Fungi as Sources of Polysaccharides for Pharmaceutical and Biomedical Applications 61
Filomena Freitas, Christophe Roca and Maria A. M. Reis
3.1 Introduction 61
3.2 The Fungal Cell 62
3.3 Polysaccharides Produced by Fungi 69
3.4 Production and Extraction of Polysaccharides from Fungi 77
3.5 Fungal Polysaccharides in Biomedical and Pharmaceutical Applications 81
3.6 Commercial Exploitation of Fungal Polysaccharides in Biomedical and Pharmaceutical Applications 89
3.7 Conclusion and Future Perspective 91
Reference 91
4 Environmentally Responsive Chitosan-based Nanocarriers (CBNs) 105
Ankit Jain and Sanjay K. Jain
4.1 Introduction 105
4.2 Graft Copolymerized CBNs 107
4.3 pH-Sensitive CBNs 109
4.4 Thermosensitive CBNs 111
4.5 pH-Sensitive and Thermosensitive CBNs 112
4.6 pH- and Ionic-Sensitive CBNs 113
4.7 Photosensitive CBNs 114
4.8 Electrical-Sensitive CBNs 115
4.9 Magneto-Responsive CBNs 115
4.10 Chemo-Sensitive CBNs 115
4.11 Biodegradation of Chitosan and Its Derivatives 116
4.12 Toxicity of CBNs 120
4.13 Conclusions and Future Perspectives 120
References 120
5 Biomass Derived and Biomass Inspired Polymers in Pharmaceutical Applications 127
Elisavet D. Bartzoka, Claudia Crestini and Heiko Lange
5.1 Introduction 127
5.2 Biodegradable Polymers in Biomedical Applications - Relevant Aspects 129
5.3 Biodegradable Natural Polymers in Pharmaceutical Applications 133
5.4 Micro- and Nanocrystalline Natural Polymers and Fibrils - General Regulative Considerations 175
5.5 Concluding Remarks and Outlook 176
Reference 177
6 Modification of Cyclodextrin for Improvement of Complexation and Formulation Properties 205
Tapan K. Dash and V. Badireenath Konkimalla
Abbreviations 205
6.1 Introduction 206
6.2 Cyclodextrin and Its Degradation 206
6.3 Complexation by CDs and Release 207
6.4 Modifications and Scope with Respect to Pharmaceutical Application 208
6.5 Concluding Remarks 218
Acknowledgements 218
Reference 218
7 Cellulose-, Ethylene Oxide- and Acrylic-Based Polymers in Assembled Module Technology (Dome Matrix®) 225
Camillo Benetti, Paolo Colombo and Tin Wui Wong
7.1 Dome MatrixR Technology 225
7.2 Polymers for Controlled Drug Release 228
7.3 Cellulose Derivatives 230
7.4 Acrylic Acid Polymers 232
7.5 Polymethacrylates 234
7.6 Polyethylene Oxide 236
7.7 Conclusions 237
Acknowledgments 237
Reference 237
8 Structured Biodegradable Polymers for Drug Delivery 243
Nishi Mody, Udita Agrawal, Rajeev Sharma and S. P. Vyas
8.1 Introduction 243
8.2 Classification 249
8.3 Degradation Processes in Biodegradable Polymers 254
8.4 Responsive Stimuli-Sensitive Polymers 260
8.5 Conclusion and Future Prospects 271
References 271
9 Current State of the Potential Use of Chitosan as Pharmaceutical Excipient 275
A. Raquel Madureira, Bruno Sarmento and Manuela Pintado
9.1 The World of Pharmaceutical Excipients 275
9.2 Chitosan 276
9.3 Activities Found for Chitosan 277
9.4 Properties of Chitosan 280
9.5 Applications as a Pharmaceutical Excipient 282
9.6 Conclusion 289
References 290
10 Modification of Gums: Synthesis Techniques and Pharmaceutical Benefits 299
Vikas Rana, Sunil Kamboj, Radhika Sharma and Kuldeep Singh
10.1 Introduction 299
10.2 Synthesis of Modified Gums 302
10.3 Characterization 320
10.4 Pharmaceutical Applications of Modified Gums 332
10.5 Conclusion and Future Prospective 354
Reference 355
11 Biomaterials for Functional Applications in the Oral Cavity via Contemporary Multidimensional Science 365
V. Tamara Perchyonok, Vanessa Reher, Nicolaas Basson and Sias Grobler
11.1 Introduction 365
11.2 Free Radical Formation, Antioxidants and Relevance in Health 366
11.3 Oral Diseases: Oxidative Stress and the Role of Antioxidant Defenses in the Oral Cavity 369
11.4 Biomaterials and Intelligent Design of Functional Biomaterials 371
11.5 In-Vitro Developments of Free Radical Defense Mechanisms and Drug-Delivery Systems 372
11.6 Practical In-Vitro Applications of Chitosan-Based Functional Biomaterial Prototypes in Dentistry 375
11.7 Conclusion 398
References 399
12 Role of Polymers in Ternary Drug Cyclodextrin Complexes 413
Renu Chadha, Madhu Bala, Parnika, Kunal Chadha and Maninder Karan
12.1 Introduction 413
12.2 Cyclodextrins (Cycloamyloses, Cyclomaltoses, Schardinger Dextrins) 414
12.3 Role of Biodegradable/Water-Soluble Polymers in Efficacy of Inclusion Complexes 416
12.4 Solubility, Dissolution and Bioavailability Enhancement: Case Studies 423
12.5 Conclusion 433
References 433
13 Collagen-Based Materials for Pharmaceutical Applications 439
Daniela Pamfil, Manuela Tatiana Nistor and Cornelia Vasile
13.1 Introduction 439
13.2 Collagen Structure and Its Properties 440
13.3 Preparation Methods of Collagen-Based Biomaterials 443
13.4 Pharmaceutical Applications of Collagen-Based Products 450
13.5 Concluding Remarks and Future Perspectives 462
Acknowledgments 468
References 468
14 Natural Polysaccharides as Pharmaceutical Excipients 483
Nazire Deniz Y¿lmaz, Gülbanu Koyundereli Ç¿lg¿ and Kenan Y¿lmaz
14.1 Introduction 483
14.2 Natural Polysaccharides 485
14.3 Conclusion 510
Reference 510
15 Structure, Chemistry and Pharmaceutical Applications of Biodegradable Polymers 517
Mazhar Ul-Islam, Shaukat Khan, Muhammad Wajid Ullah and Joong Kon Park
15.1 Introduction 517
15.2 History of Polymers 518
15.3 Concept of Biodegradability 522
15.4 Biodegradable Polymers and Their Classification 522
15.5 Biocompatibility of Biodegradable Polymers 528
15.6 Biodegradable Polymers in Pharmaceutical Applications 530
15.7 Development of Various Biodegradable Polymer Systems for Drug Delivery 532
15.8 Future Prospects 535
Acknowledgment 536
Reference 536
16 Preparation and Properties of Biopolymers: A Critical Review 541
Selvaraj Mohana Roopan, T. V. Surendra and G. Madhumitha
16.1 Introduction 541
16.2 Nature of Biopolymers 543
16.3 Common Biopolymers 544
16.4 Biopolymers in Drug Development 545
16.5 Biobased Polymers Production 548
16.6 Properties of Biopolymers 551
Acknowledgement 553
Reference 553
17 Engineering Biodegradable Polymers to Control Their Degradation and Optimize Their Use as Delivery and Theranostic Systems 557
Ilaria Armentano, Loredana Latterini, Nicoletta Rescignano, Luigi Tarpani, Elena Fortunati and Josè Maria Kenny
17.1 Introduction 557
17.2 Nanotechnology 559
17.3 Nanostructured Biodegradable Polymers 560
17.4 Design Strategies for Fluorescent Biodegradable Polymeric Systems 566
17.5 Conclusions and Perspectives 570
Reference 570
Index 577
