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Produktbild: Brook's Clinical Pediatric Endocrinology

Brook's Clinical Pediatric Endocrinology

335,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.11.2019

Herausgeber

Dattani Mehul T. + weitere

Verlag

John Wiley & Sons

Seitenzahl

810

Maße (L/B/H)

28,6/22,1/4,8 cm

Gewicht

2260 g

Auflage

7th edition

Sprache

Englisch

ISBN

978-1-119-15268-2

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.11.2019

Herausgeber

Verlag

John Wiley & Sons

Seitenzahl

810

Maße (L/B/H)

28,6/22,1/4,8 cm

Gewicht

2260 g

Auflage

7th edition

Sprache

Englisch

ISBN

978-1-119-15268-2

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Brook's Clinical Pediatric Endocrinology
  • List of Contributors xix
     
    Preface xxiii
     
    About the Companion Website xxv
     
    1 Genetics and Genomics 1
    Anu Bashamboo and Ken McElreavey
     
    Introduction 1
     
    Basic Concepts in Human Genetics and Genomics 1
     
    Classes of RNA Molecules and their Functions 4
     
    Gene Mutations and Inheritance 7
     
    Human Populations and Genetic Variation 12
     
    Epigenetics 14
     
    Advances in Genomic Analysis 15
     
    Establishing Variant Causality 19
     
    The Age of Precision Medicine 24
     
    Clinical Guidelines 24
     
    Acknowledgments 25
     
    Glossary of Terms 25
     
    Further Reading 29
     
    2 Measuring Hormones 31
    Gerhard Binder
     
    Introduction 31
     
    Hormone Assays 31
     
    Assay Validity 33
     
    Technical Pitfalls When Measuring Hormones 36
     
    Clinical Assay Validity 38
     
    Stimulation Tests, Suppression Tests and Profiles 42
     
    Optimal Clinical Use of Hormone Tests 44
     
    Acknowledgements 44
     
    References 44
     
    3 Fetal Endocrinology 47
    Harshini Katugampola, Evelien F. Gevers, and Mehul T. Dattani
     
    Introduction 48
     
    Transplacental Passage of Hormones 48
     
    Development of Fetal Endocrine Systems 50
     
    Neutralization of Hormone Activity in the Fetus 82
     
    Plasticity of Fetal Endocrine Systems 84
     
    Fetal Adaptations for Transition to Extrauterine Life 85
     
    Frontiers in Fetal and Neonatal Endocrinology 89
     
    References 90
     
    4 Disorders of Sex Development 105
    Martine Cools and Birgit Köhler
     
    Normal Sex Development 105
     
    Terminology 106
     
    Causes of DSD 107
     
    Impaired Gonadal Development 108
     
    Disturbances of Testicular Hormone Production or Action 113
     
    Virilization of an XX Individual 116
     
    Management of DSD 118
     
    Clinical Management 122
     
    Other Examples of XY DSD 126
     
    Future Perspectives 127
     
    References 127
     
    Weblinks 131
     
    5 Disorders of Hypothalamo-Pituitary Axis 133
    Hoong-Wei Gan, Kyriaki-Sandy Alatzoglou, and Mehul T. Dattani
     
    Introduction 133
     
    The Hypothalamo-Pituitary Neuroendocrine Axis 134
     
    Hypothalamo-Pituitary Development 134
     
    Congenital Disorders of Hypothalamo-Pituitary Development 144
     
    Acquired Disorders of Hypothalamo-Pituitary Dysfunction 155
     
    Investigation of Hypopituitarism 172
     
    Management of Hypopituitarism 173
     
    Conclusion 174
     
    References 174
     
    6 Disorders of Growth 199
    P.G. Murray and P.E. Clayton
     
    Normal Growth 200
     
    Short Stature 205
     
    Acquired GH Deficiency 211
     
    Disorders of GH Action and GH Sensitivity (Primary IGF-I Deficiency) 213
     
    Growth Disorders not Related to the GH-IGF Axis 216
     
    Syndromes Associated with Short Stature 219
     
    Idiopathic Short Stature 225
     
    Skeletal Dysplasias 227
     
    Tall Stature 229
     
    References 233
     
    7 Puberty and Its Disorders 235
    Sasha R. Howard, Nicolas de Roux, Juliane Leger, Jean-Claude Carel, and Leo Dunkel
     
    Normal Puberty 235
     
    Precocious Puberty 256
     
    Delayed Puberty 265
     
    Conclusions 283
     
    References 284
     
    8 The Thyroid Gland 289
    Catherine Peters and Nadia Schoenmakers
     
    Section 1: Development of the Thyroid Axis 289
     
    Section 2: Clinical Thyroid Disorders 301
     
    Section 3: Diagnostic Pitfalls 315
     
    References 320
     
    Weblinks 334
     
    9 The Adrenal Cortex and Its Disorders 335
    Claire R. Hughes, Elim Man, and John C. Acherman