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Produktbild: Introduction to Drug Disposition and Pharmacokinetics

Introduction to Drug Disposition and Pharmacokinetics

83,99 €

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.01.2017

Verlag

John Wiley & Sons Inc

Seitenzahl

336

Maße (L/B/H)

24,4/17,1/1,7 cm

Gewicht

637 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-26104-9

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.01.2017

Verlag

John Wiley & Sons Inc

Seitenzahl

336

Maße (L/B/H)

24,4/17,1/1,7 cm

Gewicht

637 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-26104-9

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Introduction to Drug Disposition and Pharmacokinetics

  • Preface ix

    Companion Website Directions xii

    1. Introduction: Basic Concepts 1

    1.1 Introduction 1

    1.2 Drugs and drug nomenclature 3

    1.3 Law of mass action 4

    1.4 Ionization 9

    1.5 Partition coefficients 12

    1.6 Further reading 14

    2. Drug Administration and Distribution 15

    2.1 Introduction 15

    2.2 Drug transfer across biological membranes 16

    2.3 Drug administration 22

    2.4 Drug distribution 31

    2.5 Plasma protein binding 38

    2.6 Further reading 43

    2.7 References 43

    3. Drug Metabolism and Excretion 45

    3.1 Introduction 45

    3.2 Metabolism 46

    3.3 Excretion 58

    3.4 Further reading 69

    3.5 References 69

    4. Single¿compartment Pharmacokinetic Models 71

    4.1 Introduction 72

    4.2 Systemic clearance 74

    4.3 Intravenous administration 76

    4.4 Absorption 79

    4.5 Infusions 87

    4.6 Multiple doses 90

    4.7 Non¿linear kinetics 94

    4.8 Relationship between dose, and onset and duration of effect 98

    4.9 Limitations of single¿compartment models 99

    4.10 Further reading 100

    4.11 References 100

    5. Multiple¿compartment and Non¿compartment Pharmacokinetic Models 102

    5.1 Multiple¿compartment models 102

    5.2 Non¿compartmental models 117

    5.3 Population pharmacokinetics 121

    5.4 Curve fitting and the choice of most appropriate model 122

    5.5 Further reading 124

    5.6 References 124

    6. Kinetics of Metabolism and Excretion 126

    6.1 Introduction 126

    6.2 Metabolite kinetics 127

    6.3 Renal excretion 137

    6.4 Excretion in faeces 142

    6.5 Further reading 143

    6.6 References 144

    7. Clearance, Protein Binding and Physiological Modelling 145

    7.1 Introduction 145

    7.2 Clearance 146

    7.3 Physiological modelling 158

    7.4 Further reading 161

    7.5 References 161

    8. Quantitative Pharmacological Relationships 162

    8.1 Pharmacokinetics and pharmacodynamics 162

    8.2 Concentration-effect relationships (dose-response curves) 163

    8.3 Time¿dependent models 169

    8.4 PK¿PD modelling 173

    8.5 Further reading 177

    8.6 References 177

    9. Pharmacokinetics of Large Molecules 178

    9.1 Introduction 178

    9.2 Pharmacokinetics 179

    9.3 Plasma kinetics and pharmacodynamics 184

    9.4 Examples of particular interest 185

    9.5 Further reading 191

    9.6 References 191

    10. Pharmacogenetics and Pharmacogenomics 192

    10.1 Introduction 192

    10.2 Methods for the study of pharmacogenetics 193

    10.3 N¿Acetyltransferase 194

    10.4 Plasma cholinesterase 197

    10.5 Cytochrome P450 polymorphisms 199

    10.6 Alcohol dehydrogenase and acetaldehyde dehydrogenase 202

    10.7 Thiopurine methyltransferase 202

    10.8 Phase 2 enzymes 202

    10.9 Transporters 204

    10.10 Ethnicity 206

    10.11 Pharmacodynamic differences 206

    10.12 Personalized medicine 208

    10.13 Further reading 209

    10.14 References 209

    11. Additional Factors Affecting Plasma Concentrations 211

    11.1 Introduction 211

    11.2 Pharmaceutical factors 213

    11.3 Sex 214

    11.4 Pregnancy 218

    11.5 Weight and obesity 220

    11.6 Food, diet and nutrition 225

    11.7 Time of day 226

    11.8 Posture and exercise 228

    11.9 Further reading 231

    11.10 References 231

    12. Effects of Age and Disease on Drug Disposition 233

    12.1 Introduction 233

    12.2 Age and development 234

    12.3 Effects of disease on drug disposition 242

    12.4 Assessing pharmacokinetics in special populations 256

    12.5 Further reading 257

    12.6 References 258

    13. Drug Interactions and Toxicity 260

    13.1 Introduction 260

    13.2 Drug interactions 261

    13.3 Toxicity 273

    13.4 Further reading 282

    13.5 References 282

    14. Perspectives and Prospects: Reflections on the Past, Present and Future of Drug Disposition and Pharmacokinetics 284

    14.1 Drug disposition and fate 284

    14.2 Pharmacodynamics 286

    14.3 Quantification of drugs and pharmacokinetics 286

    14.4 The future 289

    14.5 Postscript 291

    14.6 Further reading 292

    14.7 References 292

    Appendices

    1 Mathematical Concepts and the Trapezoidal Method 293

    2 Dye Models to Teach Pharmacokinetics 300

    3 Curve Fitting 303

    4 Pharmacokinetic Simulations 307

    Index 312