• Produktbild: Introduction to Strategies for Organic Synthesis,2nd Edition
  • Produktbild: Introduction to Strategies for Organic Synthesis,2nd Edition

Introduction to Strategies for Organic Synthesis,2nd Edition

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.04.2018

Verlag

John Wiley & Sons

Seitenzahl

422

Maße (L/B/H)

22,9/15,2/2,3 cm

Gewicht

608 g

Auflage

2. Auflage

Sprache

Englisch

ISBN

978-1-119-34724-8

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.04.2018

Verlag

John Wiley & Sons

Seitenzahl

422

Maße (L/B/H)

22,9/15,2/2,3 cm

Gewicht

608 g

Auflage

2. Auflage

Sprache

Englisch

ISBN

978-1-119-34724-8

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Introduction to Strategies for Organic Synthesis,2nd Edition
  • Produktbild: Introduction to Strategies for Organic Synthesis,2nd Edition
  • Preface xix

    Acknowlegments xxi

    CHAPTER 1 Synthetic Toolbox 1: Retrosynthesis and Protective Groups 1

    1.1 Retrosynthetic Analysis 3

    1.2 Protective Groups 11

    CHAPTER 1 Problems Protective Groups 19

    CHAPTER 2 Synthetic Toolbox 2: Overview of Organic Transformations 21

    2.1 Nucleophiles and Electrophiles 23

    2.2 Oxidation and Reduction Reactions 27

    CHAPTER 2 Problems Nucleophiles, Electrophiles, and Redox 41

    CHAPTER 3 Synthesis of Monofunctional Target Molecules (1-FG TMs) 45

    3.1 Synthesis of Alcohols (ROH) and Phenols (ArOH) 47

    3.2 Synthesis of Alkyl (RX) and Aryl Halides (ArX) 61

    3.3 Synthesis of Ethers (ROR¿) 67

    3.4 Synthesis of Thiols (RSH) and Thioethers (RSR¿) 73

    3.5 Synthesis of Amines (RNH2) and Anilines (ArNH2) 77

    3.6 Synthesis of Alkenes (R2C¿TCR2) 85

    3.7 Synthesis of Alkynes (RC¿CR¿) 93

    3.8 Synthesis of Alkanes (RH) 97

    3.9 Synthesis of Aldehydes and Ketones (RCHO, R2C¿TO) 105

    3.10 Synthesis of Carboxylic Acids (RCO2H) 117

    3.11 Synthesis of Carboxylic Acid Derivatives 125

    CHAPTER 3 Problems 1-FG TMs 139

    CHAPTER 4 Synthesis of Target Molecules with Two Functional Groups (2-FG TMs) 143

    4.1 Synthesis of ß(c)\Hydroxy Carbonyls and ¿,ß(c)\Unsaturated Carbonyls 145

    4.2 More Enolate Reactions: Synthesis of 1,3(c)\Dicarbonyls, 1,5(c)\Dicarbonyls, and Cyclohexenones 157

    4.3 "Illogical" 2(c)\Group Disconnections: Umpolung (Polarity Reversal) 171

    CHAPTER 4 Problems 2-FG TMs 183

    CHAPTER 5 Synthesis of Aromatic Target Molecules 187

    5.1 Electrophilic Aromatic Substitution (ArH + E+ ¿ ArE) 189

    5.2 Synthesis of Aromatic TMs via Diazonium Salts (ArN2 + + Nu: ¿ ArNu) 201

    5.3 Nucleophilic Aromatic Substitution (ArX + Nu: ¿ ArNu) 205

    CHAPTER 5 Problems Aromatic TMs 209

    CHAPTER 6 Synthesis of Compounds Containing Rings 211

    6.1 Synthesis of Cyclopropanes 213

    6.2 Synthesis of Cyclobutanes 215

    6.3 Synthesis of Five(c)\Membered Rings (Radical Cyclization Reactions) 217

    6.4 Synthesis of Six(c)\Membered Rings (Diels-Alder Reaction) 221

    CHAPTER 6 Problems Cyclic TMs 231

    CHAPTER 7 Predicting and Controlling Stereochemistry 235

    7.1 Reactions that Form Racemates 237

    7.2 SN2 Mechanism: Backside Attack 243

    7.3 Elimination Mechanisms 245

    7.4 Additions to Alkenes and Alkynes 247

    7.5 Additions to Carbonyls 251

    7.6 Additions to Enolates: Aldol Stereochemistry 257

    7.7 Enantioselectivity and Asymmetric Syntheses 261

    CHAPTER 7 Problems Stereochemistry 269

    CHAPTER 8 Transition Metal-Mediated Carbon-Carbon Bond Formation 273

    8.1 Transition Metal Coordination Complexes 275

    8.2 Organometallic Reaction Mechanisms 283

    8.3 Carbonylation and Decarbonylation 291

    8.4 (ArX + Alkene ¿ Ar(c)\Alkene) 295

    8.5 Palladium(c)\Catalyzed Cross(c)\Coupling Reactions (RX + R¿M ¿ R(c)\R¿) 297

    8.6 Olefin Metathesis Reactions 303

    8.7 Retrosynthesis: Disconnections Based on Metal-Mediated Reactions 307

    CHAPTER 8 Problems Transition Metal-Mediated Synthesis 309

    SOLUTIONS TO PROBLEMS 313

    Index 389