Produktbild: Bioadhesives Drug Delivery C

Bioadhesives Drug Delivery C

269,99 €

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.01.1900

Herausgeber

Mittal K. L. + weitere

Verlag

John Wiley & Sons

Seitenzahl

432

Maße (L/B/H)

22,9/15,2/2,4 cm

Gewicht

726 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-64019-6

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.01.1900

Herausgeber

Verlag

John Wiley & Sons

Seitenzahl

432

Maße (L/B/H)

22,9/15,2/2,4 cm

Gewicht

726 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-64019-6

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Bioadhesives Drug Delivery C
  • Preface xvii
     
    Part 1: Fundamental Aspects 1
     
    1 Introduction, Theories and Mechanisms of Bioadhesion 3
    Kamla Pathak and Rishabha Malviya
     
    1.1 Introduction 4
     
    1.1.1 Historical Perspective 4
     
    1.1.2 Bioadhesion in Biological Systems 5
     
    1.1.3 Bioadhesive/Mucoadhesive 6
     
    1.1.4 Factors Affecting Mucoadhesion 6
     
    1.1.4.1 Molecular Weight of Polymer 6
     
    1.1.4.2 Concentration of Polymer Used 7
     
    1.1.4.3 Flexibility of Polymer Chains 7
     
    1.1.4.4 Swelling 7
     
    1.1.4.5 pH at Polymer-Mucus Interface 7
     
    1.1.4.6 Mucin Turnover Rate 7
     
    1.1.4.7 Stereochemistry 7
     
    1.2 Bioadhesive Interactions 8
     
    1.3 The Mechanistic Approach to Bioadhesion 9
     
    1.4 Factors Controlling Bioadhesion 10
     
    1.4.1 Chemical Interactions 10
     
    1.4.1.1 Mussel Adhesion 10
     
    1.4.1.2 Cell Adhesion to Biomaterials 11
     
    1.4.2 Surface Morphology Effects 11
     
    1.4.3 Physiological Factors 12
     
    1.4.4 Physical and Mechanical Factors 12
     
    1.4.4.1 Wetting Phenomenon 12
     
    1.4.4.2 Interpenetration 12
     
    1.5 Theories of Bioadhesion 13
     
    1.5.1 Wetting Theory 13
     
    1.5.2 Diffusion Theory 15
     
    1.5.3 Electronic Theory 16
     
    1.5.4 Adsorption Theory 16
     
    1.5.5 Fracture Theory 16
     
    1.6 Stages of Mucoadhesion 17
     
    1.7 Modulation of Mucoadhesion 18
     
    1.8 Adhesion Promoters 19
     
    1.9 Surface Free Energy Analysis of Bioadhesion 19
     
    1.10 Molecular Biology in Bioadhesion 20
     
    1.11 Bioadhesives from Marine Sources 21
     
    1.12 Mucoadhesive Drug Delivery Systems 22
     
    1.13 Summary 23
     
    References 23
     
    2 Bioadhesive Polymers for Drug Delivery Applications 29
    Kenneth Chinedu Ugoeze
     
    2.1 Introduction 30
     
    2.1.1 Drug Delivery 30
     
    2.2 Bioadhesive/Mucoadhesive Drug Delivery Systems 31
     
    2.2.1 Some Advantages of Bioadhesive/Mucoadhesive Drug Delivery Systems 32
     
    2.2.2 The General Need for Bioadhesive/Mucoadhesive Drug Delivery Systems 33
     
    2.3 Mechanism of Bioadhesion 33
     
    2.4 Requirements for an Ideal Bioadhesive/Mucoadhesive Polymer 34
     
    2.5 Factors Affecting Bioadhesion/Mucoadhesion 35
     
    2.5.1 Polymer Related Factors 35
     
    2.5.1.1 Molecular Weight 36
     
    2.5.1.2 Chain Length 36
     
    2.5.1.3 Flexibility 36
     
    2.5.1.4 Cross-Linking 36
     
    2.5.1.5 Presence of Functional Groups 37
     
    2.5.1.6 Concentration of Active Polymer 37
     
    2.5.2 Environmental Factors 37
     
    2.5.2.1 pH and Charge on the Polymer 38
     
    2.5.2.2 Degree of Hydration 38
     
    2.5.2.3 Initial Contact Time 38
     
    2.5.2.4 Applied Pressure 38
     
    2.5.2.5 Swelling 39
     
    2.5.2.6 Ionic Strength 39
     
    2.5.2.7 Mucus Gel Viscosity 39
     
    2.5.3 Physiological Factors 39
     
    2.5.3.1 Mucin Turnover 39
     
    2.5.3.2 Disease States 39
     
    2.6 Bioadhesive Polymers for Drug Delivery Applications 40
     
    2.6.1 Polymers 40
     
    2.6.1.1 Natural Polymers 40
     
    2.6.1.2 Synthetic Polymers 40
     
    2.6.2 Bioadhesive/Mucoadhesive Polymers 40
     
    2.6.3 Classification of Mucoadhesive Polymers 41
     
    2.6.3.1 Classification Based on the Origin of the Polymer 41
     
    2.6.3.2 Classification Based on Aqueous Solubility of the Polymer 41
     
    2.6.3.3 Classification Based on the Type of Charge on the Polymer 42
     
    2.6.4 Natural Polymers 42
     
    2.6.4.1 Chitosan 42
     
    2.6.4.2 Starch 43
     
    2.6.4.3 Gelatin 44
     
    2.6.4.4 Alginates 44
     
    2.6.4.5 Hyalur