Produktbild: Constitutional Genomic Variation in Disease Prediction and Prevention

Constitutional Genomic Variation in Disease Prediction and Prevention Breast Cancer

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.03.2023

Herausgeber

Alison H. Trainer + weitere

Verlag

Elsevier

Seitenzahl

300

Sprache

Englisch

ISBN

978-0-323-89828-7

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.03.2023

Herausgeber

Verlag

Elsevier

Seitenzahl

300

Sprache

Englisch

ISBN

978-0-323-89828-7

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Constitutional Genomic Variation in Disease Prediction and Prevention
  • Part 1: Genomic variation and breast cancer risk
    1. Breast Cancer Epidemiology
    2. Genetics, Genomics and Genetic Pathology
    3. Mendelian Breast cancer Risk
    4. Breast Cancer Genome Wide Association Studies
    5. Functional Significance Of Intragenic Single Nucleotide Polymorphic Variations
    6. Comprehensive Genomic Breast cancer Risk Assessments
    7. Summary of current understanding of genomic of architecture and future directions: machine learning

    Part 2: Clinical Implementation
    8. Current Genetic testing in clinical practice: assessment of mutation probability, genetic counselling
    9. Variant curation, testing platforms (single gene versus panels vs exome, diagnostic versus clinical
    10. Breast Imaging, MMG Density
    11. BRCA1 and BRCA2 and PRS- clinical summary, including treatment implications
    12. Moderate risk genes and candidate breast cancer genes and PRS
    13. PRS in clinical practice
    14. Risk management: Management of high/moderate -risk mutation, expected risk management
    15. Current challenges in population screening and stratified screening (UK)
    16. Challenges of ethnicity at variant/ and physiological
    17. Genetic Counselling - implications for future practice

    Part 3: Implementation challenges: social, legal and ethical
    18. Population engagement, timing, counselling
    19. Health economics: Challenges of Economic modelling
    20. Social issues, Challenges in genetic determinism
    21. Legal and ethical issue, PGD, prenatal, insurance
    22. Relevance to other cancers / common disorders